Science Orthopedics is an international, peer-reviewed, gold open-access journal dedicated to exploring the dual dimensions of "Orthopedics" and "Science." We focus on fundamental research on the bones, joints, and musculoskeletal system, while integrating biomechanics, materials science, regenerative medicine, computational biology, and engineering. Our mission is to publish cutting-edge research that transcends disciplinary boundaries to uncover the fundamental mechanisms of disease and the principles of regeneration and repair.