Topic: Gut-Immune-Brain Axis in Neurological Disorders
A Special Issue of Microbiome Research Reports
ISSN 2771-5965 (Online)
Submission deadline: 30 Jun 2024
Guest Editor(s)
Sin-Hyeog Im, PhD
Department of Life Sciences, Pohang University of Science and Technology (POSTECH), POSTECH Biotech Center, Pohang, South Korea.
Special Issue Introduction
Special Issue Webinar: Gut-Immune-Brain Axis in Neurological Disorders
The gut microbiome plays a fundamental role in our intestinal, metabolic, and cardiovascular health. Emerging studies show that the microbes residing in our gut also play a key role in our neurological health via the intricate gut-brain or gut-microbiome-brain axis. The precise cellular/molecular mechanisms underlying and regulating this axis are only beginning to be understood. Although the gut and the brain crosstalk directly and bidirectionally via vagus nerve, emerging evidence has also revealed specific indirect mechanisms mediating this interface, including microbiome-regulated metabolites (e.g., short-chain fatty acids), neurotransmitters, hormones, and enteric nervous system. Recent studies have also highlighted the crucial role of both innate and acquired immune and inflammatory pathways involved in this gut-brain axis. Studies have shown that specific perturbations (dysbiosis) in the gut microbiome due to imprudent dietary exposures, chronic drug overuse, specific infections, endotoxemia, sepsis, or leaky gut may trigger systemic inflammation, which may in turn instigate neuroinflammation leading to neurological or neurocognitive impairment. This is in line with studies reporting that specific dietary components with anti-inflammatory or proinflammatory properties may improve or impair neurological function via gut microbiome dysbiosis. Accordingly, the gut-immune-brain axis has emerged as an important area of interest for understanding pathophysiological mechanisms and discovering novel targets and therapies for specific neurological disorders. To this end, a multidisciplinary approach covering diverse mechanisms and elements of the complex gut-immune-brain axis is imperative. In this context, this Special Issue aims to bring together state-of-the-art studies on the role of the bidirectional communications of the gut-brain axis in host neurological health and diseases, with an emphasis on microbiome-related factors and mechanisms. Researchers are invited to contribute to this Special Issue with original research articles, systematic reviews, or meta-analysis reports that can advance our understanding of the gut-immune-brain axis in relation to various neurological and neurocognitive disorders.
Topics include (but are not limited to) the role of the gut microbiome and the gut-immune-brain axis in host health and disease, as follows:
● Gut microbes and the gut-brain axis;
● The role of gut microbiome and microbial metabolites in the gut-immune-brain axis;
● The role of gut microbiome in the regulation of host neurological health via the gut-brain axis;
● Diet-microbiome-brain axis in Alzheimer's disease and related dementia;
● Gut microbiome in Multiple Sclerosis;
● Mechanisms linking the microbiome and gut-immune-brain axis in host brain health and disease;
● Gut microbiome-related neurotransmitters in gut-brain axis and neurological health;
● Microbiome and gut-brain axis in aging-associated neurocognitive decline;
● Microbiome and gut-brain axis in Parkinson's disease;
● Probiotics and Prebiotics in neurological health and disease;
● The influence of dietary and lifestyle factors on host neurological health via the gut-microbiome-brain axis;
● The role of gut microbiome and metabolites in central nervous system diseases;
● Microbiome and gut-brain axis in mental health;
● Gut-microbiota-brain axis and neurodegenerative disorders;
● The development of microbiome and gut-immune-brain interaction in early life;
● Microbiome-based therapeutic strategies to improve brain health;
● The role of the gut-immune-brain axis in anxiety and depressive disorder;
● Microbiome-immune connections in neuroinflammation, neurodegeneration, and neurological conditions;
● Microbiome and gut-brain axis in psychological stress and related disorders;
● Microbiome and gut-brain axis in major psychiatric disorders;
● Enteric nervous system in gut-brain interaction in neurological disorders;
● Microbiome and gut-brain axis in relation to brain aging;
● Leaky gut in neurological disorders;
● Microbiome and gut-brain axis in Bipolar Disorder;
● Microbiome and gut-brain axis in aging-related neurocognition decline;
● Cellular and molecular mechanisms underlying the gut-immune-brain axis.
The gut microbiome plays a fundamental role in our intestinal, metabolic, and cardiovascular health. Emerging studies show that the microbes residing in our gut also play a key role in our neurological health via the intricate gut-brain or gut-microbiome-brain axis. The precise cellular/molecular mechanisms underlying and regulating this axis are only beginning to be understood. Although the gut and the brain crosstalk directly and bidirectionally via vagus nerve, emerging evidence has also revealed specific indirect mechanisms mediating this interface, including microbiome-regulated metabolites (e.g., short-chain fatty acids), neurotransmitters, hormones, and enteric nervous system. Recent studies have also highlighted the crucial role of both innate and acquired immune and inflammatory pathways involved in this gut-brain axis. Studies have shown that specific perturbations (dysbiosis) in the gut microbiome due to imprudent dietary exposures, chronic drug overuse, specific infections, endotoxemia, sepsis, or leaky gut may trigger systemic inflammation, which may in turn instigate neuroinflammation leading to neurological or neurocognitive impairment. This is in line with studies reporting that specific dietary components with anti-inflammatory or proinflammatory properties may improve or impair neurological function via gut microbiome dysbiosis. Accordingly, the gut-immune-brain axis has emerged as an important area of interest for understanding pathophysiological mechanisms and discovering novel targets and therapies for specific neurological disorders. To this end, a multidisciplinary approach covering diverse mechanisms and elements of the complex gut-immune-brain axis is imperative. In this context, this Special Issue aims to bring together state-of-the-art studies on the role of the bidirectional communications of the gut-brain axis in host neurological health and diseases, with an emphasis on microbiome-related factors and mechanisms. Researchers are invited to contribute to this Special Issue with original research articles, systematic reviews, or meta-analysis reports that can advance our understanding of the gut-immune-brain axis in relation to various neurological and neurocognitive disorders.
Topics include (but are not limited to) the role of the gut microbiome and the gut-immune-brain axis in host health and disease, as follows:
● Gut microbes and the gut-brain axis;
● The role of gut microbiome and microbial metabolites in the gut-immune-brain axis;
● The role of gut microbiome in the regulation of host neurological health via the gut-brain axis;
● Diet-microbiome-brain axis in Alzheimer's disease and related dementia;
● Gut microbiome in Multiple Sclerosis;
● Mechanisms linking the microbiome and gut-immune-brain axis in host brain health and disease;
● Gut microbiome-related neurotransmitters in gut-brain axis and neurological health;
● Microbiome and gut-brain axis in aging-associated neurocognitive decline;
● Microbiome and gut-brain axis in Parkinson's disease;
● Probiotics and Prebiotics in neurological health and disease;
● The influence of dietary and lifestyle factors on host neurological health via the gut-microbiome-brain axis;
● The role of gut microbiome and metabolites in central nervous system diseases;
● Microbiome and gut-brain axis in mental health;
● Gut-microbiota-brain axis and neurodegenerative disorders;
● The development of microbiome and gut-immune-brain interaction in early life;
● Microbiome-based therapeutic strategies to improve brain health;
● The role of the gut-immune-brain axis in anxiety and depressive disorder;
● Microbiome-immune connections in neuroinflammation, neurodegeneration, and neurological conditions;
● Microbiome and gut-brain axis in psychological stress and related disorders;
● Microbiome and gut-brain axis in major psychiatric disorders;
● Enteric nervous system in gut-brain interaction in neurological disorders;
● Microbiome and gut-brain axis in relation to brain aging;
● Leaky gut in neurological disorders;
● Microbiome and gut-brain axis in Bipolar Disorder;
● Microbiome and gut-brain axis in aging-related neurocognition decline;
● Cellular and molecular mechanisms underlying the gut-immune-brain axis.
Keywords
Diet-Microbiome-brain interaction, gut-brain axis, gut health, microbiome and mental health, neurological disease, neurodegenerative disorders, neurocognitive health, neuroinflammation, neurotransmitters, nutrition neuroscience
Submission Deadline
30 Jun 2024
Submission Information
For Author Instructions, please refer to https://www.oaepublish.com/mrr/author_instructions
For Online Submission, please login at https://oaemesas.com/login?JournalId=mrr&SpecialIssueId=MRR230420
Submission Deadline: 30 Jun 2024
Contacts: Fiona Yin, Managing Editor, editorialoffice@mrrjournal.net
Louise Xu, Assistant Editor, Louise@microbiomeresearchreports.ne
