Special Interview with Prof. Steve Horvath

Prof. Steve Horvath is a Principal Investigator at the Altos Labs Cambridge Institute of Science, UK. He is an aging researcher and bioinformatician specializing in genomic biomarkers of aging, including the highly accurate multi-tissue epigenetic clock. His work encompasses systemic biologic approaches such as weighted gene co-expression network analysis, as well as methods for analyzing and integrating data from gene expression, DNA methylation, microRNA, genetic markers, and complex phenotypes. Prof. Horvath's research applies these methods to diverse fields including aging, cancer, cardiovascular disease, HIV, Huntington's disease, and neurodegenerative disorders. The epigenetic clock, a key achievement of his work, is notable for its high accuracy and broad applicability across tissues and cell types. Prof. Horvath has published extensively in leading journals, significantly advancing the measurement and understanding of biological aging.

Prof. Roger Foo Sik Yin is a Professor of Medicine at the Yong Loo Lin School of Medicine, National University of Singapore, Singapore. He serves as Vice-Dean (Research) and Director of the Cardiovascular Research Institute and is a senior clinician at the National University Heart Centre, Singapore. Prof. Foo is an internationally recognized cardiologist-scientist whose research focuses on cardiac genomics, epigenetics, and heart failure. His work integrates cutting-edge technologies - including genomics, CRISPR, induced pluripotent stem cells (iPSCs), and single-cell sequencing - to uncover molecular mechanisms underlying cardiac disease and identify novel therapeutic targets. He has made seminal contributions to the field, including generating one of the first DNA methylation maps of the human heart and advancing understanding of cardiac gene regulation and chromatin architecture in disease. Prof. Foo has published extensively in leading journals including Nature, Circulation, and Nature Medicine.