Tumor Microenvironment - Driven Drug Resistance

In recent years, increasing evidence has highlighted the critical role of the tumor microenvironment in shaping both intrinsic and acquired resistance. To provide a focused overview of recent progress in this area, the editors of Cancer Drug Resistance have curated a collection of research and review articles published during 2024–2025 that examine how microenvironmental factors—including endothelial cells, immune components, and extracellular vesicles—contribute to therapeutic resistance.
This collection brings together mechanistic insights and translational perspectives that may be relevant to researchers working on resistance biology, biomarker discovery, and treatment optimization.

Review

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