In recent years, natural nanoscale vesicles (e.g., exosomes, microvesicles) derived from Chinese herbal medicine—including its cells and tissue cultures—known as Chinese herbal medicine-derived extracellular vesicle-like particles (EVLPs), have rapidly emerged as a frontier in interdisciplinary research bridging life sciences and the modernization of traditional Chinese medicine. These vesicles possess unique bioactive components (nucleic acids, proteins, lipids, metabolites, etc.) and exhibit high biocompatibility, making them particularly promising for therapeutic applications. To systematically summarize the latest breakthroughs, crystallize core scientific questions, and foster deep disciplinary integration, this journal launches a Special Issue titled "Fundamental Research on Herbal Medicine-Derived Vesicles." We cordially invite scholars worldwide to contribute original research and insights to collectively map the knowledge landscape of this emerging field.

The topics covered include, but are not limited to:

1. Isolation, Purification, and Characterization Techniques:  
Development of efficient, standardized, and scalable vesicle isolation strategies (size-exclusion chromatography, polymer precipitation, microfluidics, etc.).

2. Bioactivity and Functional Mechanisms:

• Immunomodulation: Investigating how EVLPs maintain immune homeostasis and treat immune-related diseases.
• Anti-inflammatory and Tissue Repair: Evaluating the anti-inflammatory efficacy of EVLPs in diseases such as colitis, arthritis, and skin injuries, and elucidating their roles in tissue regeneration and repair.
• Anti-tumor Activity: Exploring how EVLPs inhibit tumor cell proliferation, metastasis, and angiogenesis, and their influence on tumor signaling, cell cycle regulation, apoptosis, and the tumor microenvironment.
• Targets and Signaling Pathways: Delineating how miRNAs, lncRNAs, proteins, and metabolites within EVLPs exert biological effects through specific molecular targets and signaling pathways, thus revealing their material basis and therapeutic mechanisms.