fig1
From: Receptor-mediated brain delivery in MPS II: a platform turning point for rare disease therapeutics
Figure 1. Mechanism of TfR-mediated ERT strategies. Following transcytosis, neuronal cells take up the TfR-ERT complexes via M6PRs and TfRs. TfR: Transferrin receptor; M6PR: mannose-6-phosphate receptor; ERT: enzyme replacement therapy; TfR-ERT: transferrin receptor-mediated enzyme replacement therapy.
