fig4

Figure 4. Kaplan-Meier plot of fracture-free survival stratified by DS3 score category. DS3 < 3 (mild); DS3 3- < 6 (moderate); DS3 ≥ 6 (severe). The number of patients at risk at the start of study and after 5, 10, 15, 20 years is shown above the X-axis. P values were calculated by Holm-corrected log rank-χ² tests with results including the hazard ratios, 95% confidence intervals, and the Holm P values shown in the figure. Based on the Holm P values, the fracture-free survival for the tertile with the highest DS3 scores is significantly less than for the moderate and mild DS3 severity tertiles. The difference in fracture-free survival between the moderate and mild DS3 severity tertiles is borderline, but not statistically significant (Holm P = 0.069). DS3: Disease severity scoring system; ERT: enzyme replacement therapy; CI: confidence interval; HR: hazard ratio.