fig1
From: Plexiform neurofibromas in neurofibromatosis type 1: current and emergent therapeutic strategies
Figure 1. Mechanism of MEK inhibition by selumetinib and mirdametinib. Loss of NF1 function leads to overactive Ras signaling, promoting tumor growth. Created in BioRender. Kim, H. (2025) https://BioRender.com/796ondy. NF1: Neurofibromatosis type 1; MEK 1/2: mitogen-activated protein kinase kinase; ERK: extracellular signal-regulated kinase.
