fig4
From: Gene therapy for inborn errors of immunity: past progress, current status and future directions
Figure 4. Schematic diagram showing the mechanism of adenine base editing. A gRNA targets a Cas nickase tethered to an adenine/cytosine deaminase to a specific sequence within the genome. There, specific deamination of target bases within a base editing window takes place, resulting in A:T - > G:C or C:G - > T:A transition mutations. Created in BioRender. Orf K (2025) https://BioRender.com/udxwt5j. ABEs: Adenine base editors; gRNA: guide RNA.
