REFERENCES
1. Song Y, Mehl F, Zeichner SL. Vaccine strategies to elicit mucosal immunity. Vaccines (Basel). 2024;12:191.
2. Rodríguez-Daza MC, de Vos WM. Polyphenols as drivers of a homeostatic gut microecology and immuno-metabolic traits of akkermansia muciniphila: from mouse to man. Int J Mol Sci. 2022;24:45.
3. Krawczyk M, Burzynska-Pedziwiatr I, Wozniak LA, Bukowiecka-Matusiak M. Impact of polyphenols on inflammatory and oxidative stress factors in diabetes mellitus: nutritional antioxidants and their application in improving antidiabetic therapy. Biomolecules. 2023;13:1402.
4. Scarano A, Laddomada B, Blando F, et al. The chelating ability of plant polyphenols can affect iron homeostasis and gut microbiota. Antioxidants (Basel). 2023;12:630.
5. Williamson G. Bioavailability of food polyphenols: current state of knowledge. Annu Rev Food Sci Technol. 2025;16:315-32.
6. Gutiérrez-Grijalva EP, Ambriz-Pérez DL, Leyva-López N, Castillo-López RI, Heredia JB. Bioavailability of dietary phenolic compounds: review. Rev Esp Nutr Hum Diet. 2016:20;140-7.
7. Braune A, Blaut M. Bacterial species involved in the conversion of dietary flavonoids in the human gut. Gut Microbes. 2016;7:216-34.
8. Di Pede G, Bresciani L, Brighenti F, et al.
9. Kawai Y. β-Glucuronidase activity and mitochondrial dysfunction: the sites where flavonoid glucuronides act as anti-inflammatory agents. J Clin Biochem Nutr. 2014;54:145-50.
10. Aravind S, Wichienchot S, Tsao R, Ramakrishnan S, Chakkaravarthi S. Role of dietary polyphenols on gut microbiota, their metabolites and health benefits. Food Res Int. 2021;142:110189.
11. Parkinson A, Ogilvie BW, Buckley DB, et al. Biotransformation of xenobiotics. In: Klaassen CD, Watkins JB III, editors. Casarett & Doull’s essentials of toxicology. New York: McGraw Hill; 2022. Available from: https://accesspharmacy.mhmedical.com/content.aspx?bookid=1540§ionid=92525461 [Last accessed on 11 Nov 2025].
12. Kalt W. Anthocyanins and their C6-C3-C6 metabolites in humans and animals. Molecules. 2019;24:4024.
13. Grimm T, Schäfer A, Högger P. Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (pycnogenol). Free Radic Biol Med. 2004;36:811-22.
14. Mansouri A, Embarek G, Kokkalou E, Kefalas P. Phenolic profile and antioxidant activity of the Algerian ripe date palm fruit (Phoenix dactylifera). Food Chem. 2005;89:411-20.
15. Tsai SJ, Yin MC. Anti-glycative and anti-inflammatory effects of protocatechuic acid in brain of mice treated by D-galactose. Food Chem Toxicol. 2012;50:3198-205.
16. Zhang M, Cui S, Mao B, et al. Ellagic acid and intestinal microflora metabolite urolithin A: a review on its sources, metabolic distribution, health benefits, and biotransformation. Crit Rev Food Sci Nutr. 2023;63:6900-22.
17. Andjelkovic M, Vancamp J, Demeulenaer B, et al. Iron-chelation properties of phenolic acids bearing catechol and galloyl groups. Food Chem. 2006;98:23-31.
18. Freestone PP, Walton NJ, Haigh RD, Lyte M. Influence of dietary catechols on the growth of enteropathogenic bacteria. Int J Food Microbiol. 2007;119:159-69.
19. Blander MJ, Longman RS, Iliev ID, Sonnenberg GF, Artis D. Regulation of inflammation by microbiota interactions with the host. Nat Immunol. 2017;18:851-60.
20. Bitzer ZT, Glisan SL, Dorenkott MR, et al. Cocoa procyanidins with different degrees of polymerization possess distinct activities in models of colonic inflammation. J Nutr Biochem. 2015;26:827-31.
21. Caglayan Sozmen S, Karaman M, Cilaker Micili S, et al. Resveratrol ameliorates 2,4-dinitrofluorobenzene-induced atopic dermatitis-like lesions through effects on the epithelium. PeerJ. 2016;4:e1889.
22. Han P, Yu Y, Zhang L, Ruan Z. Citrus peel ameliorates mucus barrier damage in HFD-fed mice. J Nutr Biochem. 2023;112:109206.
23. Casanova-Martí À, González-Abuín N, Serrano J, et al. Long term exposure to a grape seed proanthocyanidin extract enhances L-cell differentiation in intestinal organoids. Mol Nutr Food Res. 2020;64:e2000303.
24. Yasuda T, Takagi T, Asaeda K, et al. Urolithin A-mediated augmentation of intestinal barrier function through elevated secretory mucin synthesis. Sci Rep. 2024;14:15706.
25. Didriksen BJ, Eshleman EM, Alenghat T. Epithelial regulation of microbiota-immune cell dynamics. Mucosal Immunol. 2024;17:303-13.
26. Roager HM, Licht TR. Microbial tryptophan catabolites in health and disease. Nat Commun. 2018;9:3294.
27. Serra D, Almeida LM, Dinis TCP. Polyphenols in the management of brain disorders: Modulation of the microbiota-gut-brain axis. Adv Food Nutr Res. 2020;91:1-27.
28. Malla N, Goyal K, Dhanda RS, Yadav M. Immunity in urogenital protozoa. Parasite Immunol. 2014;36:400-8.
29. Qian C, Cao X. Dendritic cells in the regulation of immunity and inflammation. Semin Immunol. 2018;35:3-11.
30. Huang RY, Yu YL, Cheng WC, et al. Immunosuppressive effect of quercetin on dendritic cell activation and function. J Immunol. ;184:6815-21.
31. Martinez I, Gao H, Bennett GN, San KY. High yield production of four-carbon dicarboxylic acids by metabolically engineered Escherichia coli. J Ind Microbiol Biotechnol. 2018;45:53-60.
32. Yoneyama S, Kawai K, Tsuno NH, et al. Epigallocatechin gallate affects human dendritic cell differentiation and maturation. J Allergy Clin Immunol. 2008;121:209-14.
33. Williams AR, Klaver EJ, Laan LC, et al. Co-operative suppression of inflammatory responses in human dendritic cells by plant proanthocyanidins and products from the parasitic nematode Trichuris suis. Immunology. 2017;150:312-28.
34. Shakoor H, Feehan J, Apostolopoulos V, et al. Immunomodulatory effects of dietary polyphenols. Nutrients. 2021;13:728.
35. Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest. 2012;122:787-95.
36. Ferreira C, Vieira P, Sá H, et al. Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases. Front Immunol. 2024;15:1360065.
37. Hachimura S, Totsuka M, Hosono A. Immunomodulation by food: impact on gut immunity and immune cell function. Biosci Biotechnol Biochem. 2018;82:584-99.
38. Park HR, Hwang D, Suh HJ, Yu KW, Kim TY, Shin KS. Antitumor and antimetastatic activities of rhamnogalacturonan-II-type polysaccharide isolated from mature leaves of green tea via activation of macrophages and natural killer cells. Int J Biol Macromol. 2017;99:179-86.
39. Houde V, Grenier D, Chandad F. Protective effects of grape seed proanthocyanidins against oxidative stress induced by lipopolysaccharides of periodontopathogens. J Periodontol. 2006;77:1371-9.
40. Andersen-Civil AIS, Leppä MM, Thamsborg SM, Salminen JP, Williams AR. Structure-function analysis of purified proanthocyanidins reveals a role for polymer size in suppressing inflammatory responses. Commun Biol. 2021;4:896.
41. Santhakumar AB, Battino M, Alvarez-Suarez JM. Dietary polyphenols: Structures, bioavailability and protective effects against atherosclerosis. Food Chem Toxicol. 2018;113:49-65.
42. Kim YH, Won YS, Yang X, et al. Green tea catechin metabolites exert immunoregulatory effects on CD4+ T cell and natural killer cell activities. J Agric Food Chem. 2016;64:3591-7.
43. Crouvezier S, Powell B, Keir D, Yaqoob P. The effects of phenolic components of tea on the production of pro- and anti-inflammatory cytokines by human leukocytes in vitro. Cytokine. 2001;13:280-6.
44. Kawai K, Tsuno NH, Kitayama J, et al. Epigallocatechin gallate attenuates adhesion and migration of CD8+ T cells by binding to CD11b. J Allergy Clin Immunol. 2004;113:1211-7.
45. Zhou L, Wang W, Huang J, et al.
46. Cano R, Bermúdez V, Galban N, et al. Dietary polyphenols and gut microbiota cross-talk: molecular and therapeutic perspectives for cardiometabolic disease: a narrative review. Int J Mol Sci. 2024;25:9118.
47. Makarewicz M, Drożdż I, Tarko T, Duda-Chodak A. The interactions between polyphenols and microorganisms, especially gut microbiota. Antioxidants (Basel). 2021;10:188.
48. Ojo B, El-Rassi GD, Payton ME, et al. Mango supplementation modulates gut microbial dysbiosis and short-chain fatty acid production independent of body weight reduction in C57BL/6 mice fed a high-fat diet. J Nutr. 2016;146:1483-91.
49. Anhê FF, Roy D, Pilon G, et al. A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice. Gut. 2015;64:872-83.
50. Guerra-Valle M, Orellana-Palma P, Petzold G. Plant-based polyphenols: anti-helicobacter pylori effect and improvement of gut microbiota. Antioxidants (Basel). 2022;11:109.
51. Vendrame S, Guglielmetti S, Riso P, Arioli S, Klimis-Zacas D, Porrini M. Six-week consumption of a wild blueberry powder drink increases bifidobacteria in the human gut. J Agric Food Chem. 2011;59:12815-20.
52. Liu Z, Lin X, Huang G, Zhang W, Rao P, Ni L. Prebiotic effects of almonds and almond skins on intestinal microbiota in healthy adult humans. Anaerobe. 2014;26:1-6.
53. Roussel C, Chabaud S, Lessard-Lord J, et al. UPEC Colonic-virulence and urovirulence are blunted by proanthocyanidins-rich cranberry extract microbial metabolites in a gut model and a 3D tissue-engineered urothelium. Microbiol Spectr. 2022;10:e0243221.
54. Massot-Cladera M, Franch À, Pérez-Cano FJ, Castell M. Cocoa and cocoa fibre differentially modulate IgA and IgM production at mucosal sites. Br J Nutr. 2016;115:1539-46.
55. Medina-Larqué AS, Rodríguez-Daza MC, Roquim M, et al. Cranberry polyphenols and agave agavins impact gut immune response and microbiota composition while improving gut barrier function, inflammation, and glucose metabolism in mice fed an obesogenic diet. Front Immunol. 2022;13:871080.
56. Anhê FF, Nachbar RT, Varin TV, et al. Treatment with camu camu (Myrciaria dubia) prevents obesity by altering the gut microbiota and increasing energy expenditure in diet-induced obese mice. Gut. 2019;68:453-64.
57. Garcia-Vello P, Tytgat HLP, Elzinga J, et al. The lipooligosaccharide of the gut symbiont Akkermansia muciniphila exhibits a remarkable structure and TLR signaling capacity. Nat Commun. 2024;15:8411.
58. Mostafa H, Meroño T, Miñarro A, et al. Dietary sources of anthocyanins and their association with metabolome biomarkers and cardiometabolic risk factors in an observational study. Nutrients. 2023;15:1208.
59. Osborn LJ, Schultz K, Massey W, et al. A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis. Proc Natl Acad Sci U S A. 2022;119:e2202934119.
60. Yin Y, Martínez R, Zhang W, Estévez M. Crosstalk between dietary pomegranate and gut microbiota: evidence of health benefits. Crit Rev Food Sci Nutr. 2024;64:10009-35.
61. Tang JS, Stephens R, Li Y, et al. Polyphenol and glucosinolate-derived AhR modulators regulate GPR15 expression on human CD4+ T cells. J Nutr Biochem. 2023;122:109456.
62. Westfall S, Caracci F, Zhao D, et al. Microbiota metabolites modulate the T helper 17 to regulatory T cell (Th17/Treg) imbalance promoting resilience to stress-induced anxiety- and depressive-like behaviors. Brain Behav Immun. 2021;91:350-68.
63. Snyder DT, Robison A, Kemoli S, et al. Oral delivery of oligomeric procyanidins in Apple Poly® enhances type I IFN responses in vivo. J Leukoc Biol. 2014;95:841-7.
64. El-Missiry MA, Fekri A, Kesar LA, Othman AI. Polyphenols are potential nutritional adjuvants for targeting COVID-19. Phytother Res. 2021;35:2879-89.
65. Khalil A, Tazeddinova D. The upshot of Polyphenolic compounds on immunity amid COVID-19 pandemic and other emerging communicable diseases: an appraisal. Nat Prod Bioprospect. 2020;10:411-29.
66. Wu Z, Xu Q, Li A, Lv L, Li L. Apple polyphenol extract suppresses clostridioides difficile infection in a mouse model. Metabolites. 2022;12:1042.
67. Marín L, Miguélez EM, Villar CJ, Lombó F. Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties. Biomed Res Int. 2015;2015:905215.
68. Wang X, Qi Y, Zheng H. Dietary polyphenol, gut microbiota, and health benefits. Antioxidants (Basel). 2022;11:1212.
69. Al Azzaz J, Rieu A, Aires V, et al. Resveratrol-induced xenophagy promotes intracellular bacteria clearance in intestinal epithelial cells and macrophages. Front Immunol. 2018;9:3149.
70. Allam G. Immunomodulatory effects of curcumin treatment on murine schistosomiasis mansoni. Immunobiology. 2009;214:712-27.
71. Chang SY, Lee JH, Oh HJ, et al. Effect of different ratios of phytogenic feed additives on growth performance, nutrient digestibility, intestinal barrier integrity, and immune response in weaned pigs challenged with a pathogenic Escherichia coli. J Anim Sci. 2023:101.
72. Ren Z, Fang H, Zhang J, et al. Dietary Aronia melanocarpa Pomace supplementation enhances the expression of ZO-1 and occludin and promotes intestinal development in pigs. Front Vet Sci. 2022;9:904667.
73. Schytz Andersen-Civil AI, Arora P, Zhu L, et al. Gut microbiota-mediated polyphenol metabolism is restrained by parasitic whipworm infection and associated with altered immune function in mice. Gut Microbes. 2024;16:2370917.
74. Forgie AJ, Gao Y, Ju T, et al. Pea polyphenolics and hydrolysis processing alter microbial community structure and early pathogen colonization in mice. J Nutr Biochem. 2019;67:101-10.
75. Parrish A, Boudaud M, Grant ET, et al.
76. Wang LL, Shen X, Xie Y, et al. A gut Eggerthella lenta-derived metabolite impairs neutrophil function to aggravate bacterial lung infection. Sci Transl Med. 2025;17:eadq4409.
77. Winter SE, Thiennimitr P, Winter MG, et al. Gut inflammation provides a respiratory electron acceptor for Salmonella. Nature. 2010;467:426-9.
78. Sahraeian S, Rashidinejad A, Golmakani M. Recent advances in the conjugation approaches for enhancing the bioavailability of polyphenols. Food Hydrocolloids. 2024;146:109221.
79. Duda-Chodak A, Tarko T. Possible side effects of polyphenols and their interactions with medicines. Molecules. 2023;28:2536.
