REFERENCES
1. Bhattarai Y, Muniz Pedrogo DA, Kashyap PC. Irritable bowel syndrome: a gut microbiota-related disorder? Am J Physiol Gastrointest Liver Physiol. 2017;312:G52-62.
2. Van den Houte K, Carbone F, Pannemans J, et al. Prevalence and impact of self-reported irritable bowel symptoms in the general population. United Eur Gastroenterol J. 2019;7:307-15.
3. Singh SV, Ganguly R, Jaiswal K, et al. Molecular signalling during cross talk between gut brain axis regulation and progression of irritable bowel syndrome: a comprehensive review. World J Clin Cases. 2023;11:4458-76.
4. Talley NJ, Holtmann G, Walker MM. Therapeutic strategies for functional dyspepsia and irritable bowel syndrome based on pathophysiology. J Gastroenterol. 2015;50:601-13.
5. Pan CH, Chang CC, Su CT, Tsai PS. Trends in irritable bowel syndrome incidence among Taiwanese adults during 2003-2013: a population-based study of sex and age differences. PLoS One. 2016;11:e0166922.
6. Tang HY, Jiang AJ, Wang XY, et al. Uncovering the pathophysiology of irritable bowel syndrome by exploring the gut-brain axis: a narrative review. Ann Transl Med. 2021;9:1187.
7. Nasser Y, Petes C, Simmers C, et al. Activation of peripheral blood CD4+ T-cells in IBS is not associated with gastrointestinal or psychological symptoms. Sci Rep. 2019;9:3710.
8. Sciavilla P, Strati F, Di Paola M, et al. Gut microbiota profiles and characterization of cultivable fungal isolates in IBS patients. Appl Microbiol Biotechnol. 2021;105:3277-88.
9. Hou Y, Dong L, Lu X, et al. Distinctions between fecal and intestinal mucosal microbiota in subgroups of irritable bowel syndrome. Dig Dis Sci. 2022;67:5580-92.
10. Su Q, Tun HM, Liu Q, et al. Gut microbiome signatures reflect different subtypes of irritable bowel syndrome. Gut Microbes. 2023;15:2157697.
11. Simpson CA, Mu A, Haslam N, Schwartz OS, Simmons JG. Feeling down? J Affect Disord. 2020;266:429-46.
12. Pokusaeva K, Johnson C, Luk B, et al. GABA-producing Bifidobacterium dentium modulates visceral sensitivity in the intestine. Neurogastroenterol Motil. 2017:29.
13. Guimarães AP, Seidel H, Pires LVM, et al. GABA Supplementation, increased heart-rate variability, emotional response, sleep efficiency and reduced depression in sedentary overweight women undergoing physical exercise: placebo-controlled, randomized clinical trial. J Diet Suppl. 2024;21:512-26.
14. Gold MS, Loeza-Alcocer E. Experimental colitis-induced visceral hypersensitivity is attenuated by GABA treatment in mice. Am J Physiol Gastrointest Liver Physiol. 2024;326:G252-63.
15. Almutairi S, Sivadas A, Kwakowsky A. The EFFECT of Oral GABA on the nervous system: potential for therapeutic intervention. Nutraceuticals. 2024;4:241-59.
16. Oketch-Rabah HA, Madden EF, Roe AL, Betz JM. United States pharmacopeia (USP) safety review of gamma-aminobutyric acid (GABA). Nutrients. 2021;13:2742.
17. Seifi M, Swinny JD. Developmental and age-dependent plasticity of GABA(A) receptors in the mouse colon: Implications in colonic motility and inflammation. Auton Neurosci. 2019;221:102579.
18. Seifi M, Brown JF, Mills J, et al. Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon. J Neurosci. 2014;34:10361-78.
19. Baarlen P, Wells JM, Kleerebezem M. Regulation of intestinal homeostasis and immunity with probiotic lactobacilli. Trends Immunol. 2013;34:208-15.
20. Blackwood BP, Yuan CY, Wood DR, Nicolas JD, Grothaus JS, Hunter CJ. Probiotic lactobacillus species strengthen intestinal barrier function and tight junction integrity in experimental necrotizing enterocolitis. J Probiotics Health. 2017;5:159.
21. Laroute V, Aubry N, Audonnet M, Mercier-Bonin M, Daveran-Mingot ML, Cocaign-Bousquet M. Natural diversity of lactococci in γ-aminobutyric acid (GABA) production and genetic and phenotypic determinants. Microb Cell Fact. 2023;22:178.
22. Siragusa S, De Angelis M, Di Cagno R, Rizzello CG, Coda R, Gobbetti M. Synthesis of gamma-aminobutyric acid by lactic acid bacteria isolated from a variety of Italian cheeses. Appl Environ Microbiol. 2007;73:7283-90.
23. Karimian E, Moayedi A, Khomeiri M, Aalami M, Mahoonak AS. Application of high-GABA producing Lactobacillus plantarum isolated from traditional cabbage pickle in the production of functional fermented whey-based formulate. Food Measure. 2020;14:3408-16.
24. Rieger J, Pelckmann LM, Drewes B. Preservation and processing of intestinal tissue for the assessment of histopathology. Methods Mol Biol. 2021;2223:267-280.
25. An S, Zong G, Wang Z, Shi J, Du H, Hu J. Expression of inducible nitric oxide synthase in mast cells contributes to the regulation of inflammatory cytokines in irritable bowel syndrome with diarrhea. Neurogastroenterol Motil. 2016;28:1083-93.
26. Kuiken SD, Klooker TK, Tytgat GN, Lei A, Boeckxstaens GE. Possible role of nitric oxide in visceral hypersensitivity in patients with irritable bowel syndrome. Neurogastroenterol Motil. 2006;18:115-22.
27. Coutinho SV, Gebhart GF. A role for spinal nitric oxide in mediating visceral hyperalgesia in the rat. Gastroenterology. 1999;116:1399-408.
28. Hasler WL, Grabauskas G, Singh P, Owyang C. Mast cell mediation of visceral sensation and permeability in irritable bowel syndrome. Neurogastroenterol Motil. 2022;34:e14339.
29. Xie Z, Feng J, Hibberd TJ, et al. Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity. Neuron. 2023;111:526-538.e4.
30. Yao K, Dou B, Zhang Y, et al. Inflammation-the role of TRPA1 channel. Front Physiol. 2023;14:1093925.
31. Gao N, Li M, Wang W, Liu Z, Guo Y. The dual role of TRPV1 in peripheral neuropathic pain: pain switches caused by its sensitization or desensitization. Front Mol Neurosci. 2024;17:1400118.
32. Chen M, Ruan G, Chen L, et al. Neurotransmitter and intestinal interactions: focus on the microbiota-gut-brain axis in irritable bowel syndrome. Front Endocrinol (Lausanne). 2022;13:817100.
33. Deng Z, Li D, Yan X, et al. Activation of GABA receptor attenuates intestinal inflammation by modulating enteric glial cells function through inhibiting NF-κB pathway. Life Sci. 2023;329:121984.
35. Shi HJ, Wang S, Wang XP, Zhang RX, Zhu LJ. Hippocampus: molecular, cellular, and circuit features in anxiety. Neurosci Bull. 2023;39:1009-26.
36. Bowman R, Frankfurt M, Luine V. Sex differences in anxiety and depression: insights from adult rodent models of chronic stress and neural plasticity. Front Behav Neurosci. 2025;19:1591973.
37. Xu Y, Li LN, He XJ, et al. Exogenous GABA alleviates tourette syndrome-like behavior in sprague-dawley rats by altering gut microbiota and striatum metabolism. Neuropsychiatr Dis Treat. 2025;21:711-27.
38. Berthoud HR, Neuhuber WL. Functional and chemical anatomy of the afferent vagal system. Auton Neurosci. 2000;85:1-17.
39. Meerschaert KA, Chiu IM. The gut-brain axis and pain signalling mechanisms in the gastrointestinal tract. Nat Rev Gastroenterol Hepatol. 2025;22:206-21.
40. Tette FM, Kwofie SK, Wilson MD. Therapeutic anti-depressant potential of microbial GABA produced by lactobacillus rhamnosus strains for GABAergic signaling restoration and inhibition of addiction-induced HPA axis hyperactivity. Curr Issues Mol Biol. 2022;44:1434-51.
41. Bravo JA, Forsythe P, Chew MV, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A. 2011;108:16050-5.
42. Siopi E, Galerne M, Rivagorda M, et al. Gut microbiota changes require vagus nerve integrity to promote depressive-like behaviors in mice. Mol Psychiatry. 2023;28:3002-12.
43. Ghia JE, Blennerhassett P, Kumar-Ondiveeran H, Verdu EF, Collins SM. The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model. Gastroenterology. 2006;131:1122-30.
44. Ondicova K, Tillinger A, Pecenak J, Mravec B. The vagus nerve role in antidepressants action: efferent vagal pathways participate in peripheral anti-inflammatory effect of fluoxetine. Neurochem Int. 2019;125:47-56.
45. Zou Q, Han S, Liang J, et al. Alleviating effect of vagus nerve cutting in Salmonella-induced gut infections and anxiety-like behavior via enhancing microbiota-derived GABA. Brain Behav Immun. 2024;119:607-20.