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From: Faecalibacterium prausnitzii A2-165 metabolizes host- and media-derived chemicals and induces transcriptional changes in colonic epithelium in GuMI human gut microphysiological system

<i>Faecalibacterium prausnitzii</i> A2-165 metabolizes host- and media-derived chemicals and induces transcriptional changes in colonic epithelium in GuMI human gut microphysiological system

Figure 4. F. prausnitzii has a higher impact than the microenvironment on the expression of transcription factor genes in the colonic epithelial cells. (A)Volcano plot on the gene expression of transcription factors in GuMI-FP vs. GuMI-NB. The 260 significantly changed genes (P 1) are highlighted in red; and (B) volcano plot on the gene expression of transcription factors in GuMI-NB vs. GuMI-FP. The 27 significantly changed genes (P 1) are highlighted in red; (C) Venn plot on the significantly changed transcription factor indicates the unique effects of F. prausnitzii. Seventeen transcription factors are changed by microenvironment change (NB vs. Static) and F. prausnitzii (FP vs. NB). GuMI-FP: GuMI with F. prausnitzii; GuMI-NB: GuMI without bacteria.