fig4

Figure 4. Presence of genes for the biosynthesis of chorismate, pABA, DHPPP, and THF-polyglutamate pathways and prediction of folate synthesis from the sequenced genomes of type strains of bifidobacterial species so far described. Chorismate pathway comprises aroG 2.5.1.54, aroBK 4.2.3.4, aroQ 4.2.1.10, aroE 1.1.1.25, aroBK 2.7.1.71, aroA 2.5.1.19 and aroC 4.2.3.5; ^bpABA pathway comprise pabA 2.6.1.85 and pabC 4.1.3.38; ^cDHPP pathway comprises folE 3.5.4.16, 3.1.3.1, 3.6.1.-, folBK 4.1.2.25, folBK 2.7.63; ^dTHF-polyglud pathway comprises folP 2.5.1.15, folC 6.3.2.12/17, dfrA 1.5.1.3. Rectangels in green: all genes of the pathway are present; rectangels in red: at least one gene of the pathway is absent. In the right you will find the folate production prediction based on th epresence of pathwas genes: in blue: predicted folate production; in yellow: pABA needed for predicted folate production; in brown, no predicted folate production; ^eall the genes for the biosynthesis of DHPPP are present, with the exception of alkaline phosphatase (EC 3.1.3.1). The dephosphorylation of dihydroneopterin triphosphate into the monophosphate can occur through an alternative route using pyrophosphohydrolase number EC 3.6.1.-. which is present (Rossi 2011).