fig6

Figure 6. The predicted structure of Aquarius gp41 resembles factors that facilitate protein-protein interactions. (A) Aquarius gp41structure predicted by AlphaFold2. Structure is colored by confidence and functional motifs are labeled; (B) Closest structural homologs to Aquarius gp41 as determined by the DALI structural homology server - Vir8B (Green: pdbid is 6IQT) and mouse Cystatin (orange:pdbid 6UIO); (C) Structural alignment between gp41 95-179 (blue) and mouse cystatin (orange); (D) Electrostic potential was solved using the APBS for Aquarius gp41 (left) and TP-J34 Ltp (right). Electrostatic potential scale is given in kT/e where negative (red) and positive (blue) surface potentials are shown. APBS: Adaptive Poisson-Boltzmann Solver.