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Figure 2. Impact of Sequencing technology, sequencing depth and k-mer length on the correlation between expected taxonomic and k-mer-based beta-diversity metric. (A) Spearman correlations between the expected taxonomic and k-mer-based Bray-Curtis distance using the HiSeq sequencing error model; (B) Expected taxonomic against the k-mer-based Bray-Curtis distances (k = 30bp) obtained for a simulated dataset of 100 metagenomes simulated at a sequencing depth of 5 million paired reads using the HiSeq sequencing error model; (C) Spearman correlations between the expected taxonomic and k-mer-based presence/absence Jaccard distance using the HiSeq sequencing error model; (D) Expected taxonomic against the k-mer-based presence/absence Jaccard distances (k = 30bp) obtained for a simulated dataset of 100 metagenomes simulated at a sequencing depth of 5 million paired-reads using the HiSeq sequencing error model.