fig4
From: Gastric organoid/organ-on-a-chip platforms for disease modeling and personalized medicine: a review
Figure 4. OoC for gastric mucosa modeling. (A) Microfluidic system for studying the barrier function of stomach mucin. Reproduced from Ref.[68]. Copyright 2012, Royal Society of Chemistry; (B) Stomach organoid-on-a-chip with luminal flow to induce cyclic mechanical deformation of the organoids, simulating gastric motility. Scale bars: 2 mm. Reproduced from Ref.[22]. Copyright 2018, Royal Society of Chemistry; (C) Stomach-on-a-chip with an epithelial cell monolayer, basement membrane, and the lamina propria to recapitulate human gastric mucosa architecture. Reproduced from Ref.[71]. Copyright 2023, Royal Society of Chemistry. PDMS: Polydimethylsiloxane; hGO: human gastric organoid; ECM: extracellular matrix; OoC: organ-on-a-chip.
