fig3

From: Gastric organoid/organ-on-a-chip platforms for disease modeling and personalized medicine: a review

Figure 3. Gastric organoids used for drug response evaluation and disease development mechanism investigations. (A) GC PDO-mediated interpretation of resistance to 5-FU and CDDP combination therapy. Reproduced from Ref.^[61] under the terms of the CC BY 4.0 License; (B) Generation of multiregional assembloids for the patient-specific recapitulation of antral foveolar hyperplasia. Reproduced from Ref.^[64] under the terms of the CC BY 4.0 License. JAK-STAT: Janus Kinase-Signal Transducer and Activator of Transcription; ADAR1: adenosine deaminase acting on RNA 1; ER: endoplasmic reticulum; LD: lipid droplet; SCD1: stearoyl-CoA desaturase; 5FU: 5-fluorouracil; CDDP: cisplatin; GC: gastric cancer; PDO: patient-derived organoid; SRA: single-region assembloid; MRA: multiregional assembloid; HC: healthy control; MUC5AC: Mucin 5AC.