fig4

From: Mitochondria-targeting amphiphilic polymers enable idebenone to promote neuronal regeneration following spinal cord injury

Figure 4. Functional and structural recovery after SCI. (A) BMS scores of each treatment group on the 1st, 3rd, 5th, and 7th day, and once a week until 8 weeks after model establishment. SP@I vs. P@I, P < 0.0001 (Day 7-56), P@I vs. PBS, P < 0.0001 (Day 14-56); (B) The area of the paw contacting the ground; (C) Footprints of mice in each treatment group on day 56; (D) The intensity of paw contact with the ground in each group on day 56; (E) Spinal cord morphology on day 56 for each treatment group; (F) Nissl staining of the spinal cord in each treatment group at 8 weeks. The upper scale bar is 1,000 μm, and the lower scale bar is 200 μm. Data are expressed as the mean ± SD (n = 3). PBS: Phosphate-buffered saline; LF: left forelimb; LH: Left hindlimb; RF: Right forelimb; RH: Right hindlimb. SCI: spinal cord injury; BMS: basso mouse scale; SD: standard deviation.