fig4

Figure 4. mRNA -LNP reversal model of pulmonary fibrosis in mice[96]. CYB5R3: Cytochrome b5 reductase 3; BMP4: bone morphogenetic protein 4; ECM: excessive extracellular matrix; LNP: lipid nanoparticle. TGF: Transforming growth factor; NADH: nicotinamide adenine dinucleotide (reduced form); NAD+: nicotinamide adenine dinucleotide (oxidized form); SAAP: senescene-associated secretory phenotype; AT1: alveolar type 1 epithelial cells.