fig2

From: Advances in sudden unexplained death: novel insights into technical innovations and their applications in forensic investigation

Figure 2. Conceptual timeline of major concepts and technique advances in SUDs. With the advancement of new technologies, the proportion of solved SUD cases has progressively increased over the past century. Solid arrow indicates the year that a concept or disease entity was first defined or formally named, or pathogenic gene was first reported in the literature. Gray dashed arrow indicates the downward trend in the proportion of SUDs. Created in BioRender. qi, M. (2026) https://BioRender.com/vxgvd6z. SUDS: Sudden unexplained death syndrome; LQTS: long QT syndrome; SIDS: sudden infant death syndrome; BrS: Brugada syndrome; CPVT: catecholaminergic polymorphic ventricular tachycardia; SUDEP: sudden unexpected death in epilepsy; SQTS: short QT syndrome; SADS: sudden arrhythmic death syndrome; AI: artificial intelligence; SVM: support vector machine; PMCT: postmortem computed tomography; CNN: convolutional neural network; PMMRI: postmortem magnetic resonance imaging; PMCTA: postmortem computed tomography angiography; NGS: next-generation sequencing; FTIR: Fourier transform infrared; WES: whole-exome sequencing; ACMG: American College of Medical Genetics and Genomics; DANN: deleterious annotation of genetic variants using neural networks.