fig3

Figure 3. The m6A machinery acts as a double-edged sword in periodontitis and related conditions. (Created with Figdraw; ID: IIOTU9a2ca). Runx2: RUNX family transcription factor 2; YAP: yes1 associated transcriptional regulator; IGF2BP: insulin-like growth factor 2 mRNA-binding protein; YTHDF: YTH N6-methyladenosine RNA binding protein F; METTL3: methyltransferase-like 3; FTO: fat mass and obesity-associated protein; eIF3a: eukaryotic translation initiation factor 3 subunit A; MAPK: mitogen-activated protein kinase; NF-κ B: nuclear factor-kappa B; BMSC: bone marrow mesenchymal stem cell; PDLC: periodontal ligament cell; HGF: human gingival fibroblast; SLC39A9: solute carrier family 39 member 9; IL-6: interleukin 6; NLRP3: NLR family pyrin domain containing 3; TNFAIP3: TNF alpha induced protein 3; HK1: hexokinase 1; CDK2: cyclin dependent kinase 2; SOST: sclerostin; Mcp1: monocyte chemoattractant protein 1; Mmp9: matrix metallopeptidase 9; RANK: receptor activator of NF-κB; m6A: N6-methyladenosine.