fig1
From: SMN2 as a therapeutic target in spinal muscular atrophy: advances in gene expression modulation
Figure 1. Differential Splicing of SMN1 and SMN2 Genes and Its Impact on SMN Protein Levels. Although nearly identical to SMN1, the SMN2 gene contains a single C-to-T substitution at codon 280 in exon 7. This silent mutation disrupts splicing, leading to exon 7 skipping in most transcripts and reduced production of full-length, functional SMN protein. Created in BioRender. Virata MCA, (2025) https://BioRender.com/6u6sj1t
