fig2

Figure 2. Overview of the forward MR based on IVW. (A) Associations from IDPs to stroke, including regional and tissue volume, cortical area, cortical thickness, and WM tract ICVF. (B) Associations from stroke to IDPs, including regional T2*, WM tract FA, WM tract diffusivity, WM tract OD, and WM tract ISOVF. A Bonferroni-corrected significance threshold was set at P < 0.001 {0.05/[10 IDP categories × 5 stroke types]}. Only significant associations observed in both directions are presented. IDPs: Imaging-derived phentypes; WM: white matter; ICVF: intra-cellular volume fraction; FA: fractional anisotropy; OD: orientation dispersion index; ISOVF: isotropic or free water volume fraction; MR: mendelian randomization; IVW: including inverse variance weighted.