fig1

Figure 1. Workflow of the causal inference between IDPs and stroke. Genome-wide significant SNPs (P < 5e-8, r² ≤ 0.2) were used to assess associations from IDPs to stroke (forward MR) and from stroke to IDPs (reverse MR). IDPs are divided into 10 categories and stroke is divided into 5 subtypes. MR methods include inverse variance weighted, weighted median, weighted mode, simple mode, and MR Egger, and sensitivity analyses include leave-one-out, Cochran’s Q, and MR Egger. IDPs: Imaging-derived phentypes; WM: white matter; FA: fractional anisotropy; MO: diffusion tensor mode; ICVF: intra-cellular volume fraction; OD: orientation dispersion index; AS: all stroke; AIS: all ischemic stroke; CES: CardioEmbolic stroke; SVS: small vessel stroke; LAS: large artery stroke; MR: mendelian randomization.