fig5

Figure 5. Bivariate exposure-response functions of non-persistent pesticide mixtures and sex hormone levels in postmenopausal women based on the BKMR model. (A-D) Bivariate functions for TT, FAI, E2, and SHBG, respectively. For each biomarker, the estimate was calculated with the second biomarker fixed at the 25th, 50th, and 75th percentiles. BKMR: Bayesian kernel machine regression; TT: total testosterone; FAI: free androgen index; E2: estradiol; SHBG: sex hormone-binding globulin; 3-PBA: 3-phenoxybenzoic acid; TCPY: 3,5,6-trichloro-2-pyridinol; PNP: para-nitrophenol; 2,4-D: 2,4-dichlorophenoxyacetic acid.