fig4

Figure 4. Estimated overall association between the mixture of the four heavy metal(loid)s and the outcome (Box-Cox-transformed eGFR) across quantiles of the mixture distribution, based on the BKMR model. The 50th percentile (median) of the exposure mixture is used as the reference point (estimate = 0.0; horizontal dashed line). Points represent posterior mean estimates, and vertical lines indicate 95% credible intervals. eGFR: Estimated glomerular filtration rate; BKMR: Bayesian Kernel Machine Regression.