fig2

Figure 2. Estimated change in Box-Cox-transformed eGFR (outcome) associated with changes in urinary metal(loid) concentrations, based on BKMR. Points represent the mean estimated difference in predicted outcome when the log-transformed concentration of one metal(loid) increases from the 25th to the 75th percentile, while the other three are held constant at the 25th (red), 50th (green), or 75th (blue) percentile. Horizontal lines indicate 95% credible intervals. The x-axis shows the estimated change in the outcome; the vertical dashed line at 0.00 indicates no change. Values < 0.00 suggest a negative association; values > 0.00 suggest a positive association. eGFR: Estimated glomerular filtration rate; BKMR: Bayesian Kernel Machine Regression.