fig7

Arginine metabolism disruption mediates 6-PPD quinone-induced mitochondrial toxicity at environmentally relevant concentrations in <i>Caenorhabditis elegans</i>

Figure 7. Effect of administration with 10 mM arginine on toxicity of 10 μg/L 6-PPDQ on mitochondrial function. (A) Effect of administration with arginine on 6-PPDQ toxicity in increasing oxygen consumption rate; (B) Effect of administration with arginine on 6-PPDQ toxicity in decreasing ATP content; (C) Effect of administration with arginine on 6-PPDQ toxicity in decreasing expression of sod-3 and hsp-6; (D) Effect of administration with arginine on 6-PPDQ toxicity in decreasing expression of SOD-3::GFP and HSP-6::GFP; (E) Effect of administration with arginine on 6-PPDQ toxicity in decreasing expression of gas-1 and mev-1. **P < 0.01. 6-PPDQ: N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone; SOD-3: Superoxide Dismutase 3; GFP: green fluorescent protein; HSP-6: Heat Shock Protein 6; gas-1: General Anaesthetic Sensitivity abnormal; mev-1: abnormal MEthyl Viologen sensitivity.

Journal of Environmental Exposure Assessment
ISSN 2771-5949 (Online)

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