Journal of Environmental Exposure Assessment

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From: Arginine metabolism disruption mediates 6-PPD quinone-induced mitochondrial toxicity at environmentally relevant concentrations in Caenorhabditis elegans

Arginine metabolism disruption mediates 6-PPD quinone-induced mitochondrial toxicity at environmentally relevant concentrations in <i>Caenorhabditis elegans</i>

Figure 6. Effect of RNAi of argn-1 on expressions of gas-1, mev-1, sod-3, and hsp-6 in 6-PPDQ-exposed nematodes. (A) Effect of RNAi of argn-1 on expressions of gas-1 and mev-1 in 6-PPDQ-exposed nematodes; (B) Effect of RNAi of argn-1 on expressions of sod-3 and hsp-6 in 6-PPDQ-exposed nematodes; (C) Effect of RNAi of argn-1 on expressions of SOD-3::GFP and HSP-6::GFP in 6-PPDQ-exposed nematodes. Exposure concentration of 6-PPDQ was 10 μg/L. ^**P < 0.01. gas-1: General Anaesthetic Sensitivity abnormal; mev-1: abnormal MEthyl Viologen sensitivity; sod-3: Superoxide Dismutase 3; hsp-6: Heat Shock Protein 6; 6-PPDQ: N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone; RNAi: RNA interference; GFP: green fluorescent protein.