fig2

Arginine metabolism disruption mediates 6-PPD quinone-induced mitochondrial toxicity at environmentally relevant concentrations in <i>Caenorhabditis elegans</i>

Figure 2. Effect of 6-PPDQ exposure on arginine absorption. (A) Effect of 6-PPDQ exposure on expression of intestinal aat-1 and C50D2.2. Thirty intact intestines were isolated for qRT-PCR analysis. **P < 0.01 vs. control. (B) Effect of intestinal RNAi of aat-1 and C50D2.2 on arginine content in 6-PPDQ-exposed nematodes. Exposure concentration of 6-PPDQ was 10 μg/L. **P < 0.01 vs. VP303(L44440). 6-PPDQ: N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone; aat-1: amino acid transporter 1; qRT-PCR: quantitative real-time polymerase chain reaction.

Journal of Environmental Exposure Assessment
ISSN 2771-5949 (Online)

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