fig6

6-PPD quinone-inhibited retinoic acid synthesis mediates toxicity through feedback loop between ALH-3/DHS-19-SEX-1 axis and intestinal signals in <i>Caenorhabditis elegans</i>

Figure 6. Effect of RNAi of sex-1 on 6-PPDQ toxicity. (A) Effect of RNAi of sex-1 on 6-PPDQ toxicity in inducing ROS generation; (B) Effect of RNAi of sex-1 on 6-PPDQ toxicity in decreasing locomotion behavior; (C) Effect of RNAi of sex-1 on 6-PPDQ toxicity in reducing brood size. Exposure concentration of 6-PPDQ was 10 μg/L. **P < 0.01. RNA interference; 6-PPDQ: N’-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine quinone; ROS: reactive oxygen species.

Journal of Environmental Exposure Assessment
ISSN 2771-5949 (Online)

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