fig1

Figure 1. Overall association between the mixture of heavy metals (blood arsenic, cadmium, mercury, and lead) and urinary oxidative stress biomarkers in Uruguayan adolescents (n = 361)¹. (A) 8-OhdG; (B) F2-isoprostanes. ¹The metals in the mixture were log10-transformed and standardized. The mixture was modeled as increasing from the 25th to the 75th percentile in 5% increments. Models were adjusted for age, sex, BMI, SES, illness symptoms, physical activity score, and secondhand smoke exposure. 8-OHdG: 8-Hydroxy-2’-deoxyguanosine; BMI: body mass index; SES: socioeconomic status.