The Sub1-p53 axis in cardiac aging and HFpEF

Ning Xia

doi:10.20517/jca.2026.127

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Commentary Open Access 21 Oct 2026

The Sub1-p53 axis in cardiac aging and HFpEF

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Ning Xia

J Cardiovasc Aging. 2026;6:50. 10.20517/jca.2026.127

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REFERENCES

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2. Zhao D, Wang Y, Wong ND, Wang J. Impact of aging on cardiovascular diseases: from chronological observation to biological insights: JACC family series. JACC Asia. 2024;4:345-58.

3. Køber L, Adamo M, Ruwald AC, et al.; ESC Guidelines Advisory Group. 2026 ESC Guidelines for the management of heart failure. Eur Heart J. 2026;47:5346-457.

4. Redfield MM, Borlaug BA. Heart failure with preserved ejection fraction: a review. JAMA. 2023;329:827-38.

5. Abdellatif M, Rainer PP, Sedej S, Kroemer G. Hallmarks of cardiovascular ageing. Nat Rev Cardiol. 2023;20:754-77.

6. Ge H, Roeder RG. Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes. Cell. 1994;78:513-23.

7. Calvo O. Sub1 and RNAPII, until termination does them part. Transcription. 2018;9:52-60.

8. Sikder S, Kumari S, Mustafi P, et al. Nonhistone human chromatin protein PC4 is critical for genomic integrity and negatively regulates autophagy. FEBS J. 2019;286:4422-42.

9. Zhao D, Lin L, Zhou Y, et al. Sub1 contributes to heart failure with preserved ejection fraction driven by aging in mice. Nat Commun. 2026;17:8332.

10. Ungvari Z, Tarantini S, Donato AJ, Galvan V, Csiszar A. Mechanisms of vascular aging. Circ Res. 2018;123:849-67.

11. Picos A, Seoane N, Campos-Toimil M, Viña D. Vascular senescence and aging: mechanisms, clinical implications, and therapeutic prospects. Biogerontology. 2025;26:118.

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The Sub1-p53 axis in cardiac aging and HFpEF

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Xia N. The Sub1-p53 axis in cardiac aging and HFpEF. J Cardiovasc Aging. 2026;6:50. https://dx.doi.org/10.20517/jca.2026.127

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DOI: https://doi.org/10.20517/jca.2026.127

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