REFERENCES

1. Tsao CW, Aday AW, Almarzooq ZI, et al. Heart disease and stroke statistics-2023 update: a report from the american heart association. Circulation 2023;147:e93-621.

2. DeFilippis EM, Van Spall HGC. Is it time for sex-specific guidelines for cardiovascular disease? J Am Coll Cardiol 2021;78:189-92.

3. Paz Ocaranza M, Riquelme JA, García L, et al. Counter-regulatory renin-angiotensin system in cardiovascular disease. Nat Rev Cardiol 2020;17:116-29.

4. Miller AJ, Arnold AC. The renin-angiotensin system and cardiovascular autonomic control in aging. Peptides 2022;150:170733.

5. Wang M, Khazan B, Lakatta EG. Central arterial aging and angiotensin II signaling. Curr Hypertens Rev 2010;6:266-81.

6. DuPont JJ, Kim SK, Kenney RM, Jaffe IZ. Sex differences in the time course and mechanisms of vascular and cardiac aging in mice: role of the smooth muscle cell mineralocorticoid receptor. Am J Physiol Heart Circ Physiol 2021;320:H169-80.

7. Berry C, Touyz R, Dominiczak AF, Webb RC, Johns DG. Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide. Am J Physiol Heart Circ Physiol 2001;281:H2337-65.

8. Peluso AA, Bertelsen JB, Andersen K, et al. Identification of protein phosphatase involvement in the AT2 receptor-induced activation of endothelial nitric oxide synthase. Clin Sci 2018;132:777-90.

9. Steckelings UM, Widdop RE, Sturrock ED, et al. The angiotensin AT2 receptor: from a binding site to a novel therapeutic target. Pharmacol Rev 2022;74:1051-135.

10. You D, Loufrani L, Baron C, Levy BI, Widdop RE, Henrion D. High blood pressure reduction reverses angiotensin II type 2 receptor-mediated vasoconstriction into vasodilation in spontaneously hypertensive rats. Circulation 2005;111:1006-11.

11. Sampson AK, Moritz KM, Jones ES, Flower RL, Widdop RE, Denton KM. Enhanced angiotensin II type 2 receptor mechanisms mediate decreases in arterial pressure attributable to chronic low-dose angiotensin II in female rats. Hypertension 2008;52:666-71.

12. Touyz RM, Endemann D, He G, Li JS, Schiffrin EL. Role of AT2 receptors in angiotensin II-stimulated contraction of small mesenteric arteries in young SHR. Hypertension 1999;33:366-72.

13. Viswanathan M, Tsutsumi K, Correa FM, Saavedra JM. Changes in expression of angiotensin receptor subtypes in the rat aorta during development. Biochem Biophys Res Commun 1991;179:1361-7.

14. Chatziantoniou C, Arendshorst WJ. Angiotensin receptor sites in renal vasculature of rats developing genetic hypertension. Am J Physiol 1993;265:F853-62.

15. Savoia C, Touyz RM, Volpe M, Schiffrin EL. Angiotensin type 2 receptor in resistance arteries of type 2 diabetic hypertensive patients. Hypertension 2007;49:341-6.

16. Lang JA, Krajek AC. Age-related differences in the cutaneous vascular response to exogenous angiotensin II. Am J Physiol Heart Circ Physiol 2019;316:H516-21.

17. Schwartz KS, Lang JA, Stanhewicz AE. Angiotensin II type 2 receptor-mediated dilation is greater in the cutaneous microvasculature of premenopausal women compared with men. J Appl Physiol 2023;135:1236-42.

18. Herrick AL, Batta R, Overbeck K, et al. A phase 2 trial investigating the effects of the angiotensin II type 2 receptor agonist C21 in systemic sclerosis-related Raynaud’s. Rheumatology 2023;62:824-8.

19. Tornling G, Batta R, Porter JC, et al. Seven days treatment with the angiotensin II type 2 receptor agonist C21 in hospitalized COVID-19 patients; a placebo-controlled randomised multi-centre double-blind phase 2 trial. EClinicalMedicine 2021;41:101152.

20. Xue B, Pamidimukkala J, Hay M. Sex differences in the development of angiotensin II-induced hypertension in conscious mice. Am J Physiol Heart Circ Physiol 2005;288:H2177-84.

21. Xue B, Pamidimukkala J, Lubahn DB, Hay M. Estrogen receptor-alpha mediates estrogen protection from angiotensin II-induced hypertension in conscious female mice. Am J Physiol Heart Circ Physiol 2007;292:H1770-6.

22. Tatchum-Talom R, Eyster KM, Martin DS. Sexual dimorphism in angiotensin II-induced hypertension and vascular alterations. Can J Physiol Pharmacol 2005;83:413-22.

23. Widdop RE, Vinh A, Henrion D, Jones ES. Vascular angiotensin AT2 receptors in hypertension and ageing. Clin Exp Pharmacol Physiol 2008;35:386-90.

24. Koike G, Horiuchi M, Yamada T, Szpirer C, Jacob HJ, Dzau VJ. Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung. Biochem Biophys Res Commun 1994;203:1842-50.

25. Mishra JS, Hankins GD, Kumar S. Testosterone downregulates angiotensin II type-2 receptor via androgen receptor-mediated ERK1/2 MAP kinase pathway in rat aorta. J Renin Angiotensin Aldosterone Syst 2016;17:147032031667487.

26. Mishra JS, Te Riele GM, Qi QR, et al. Estrogen receptor-β mediates estradiol-induced pregnancy-specific uterine artery endothelial cell angiotensin type-2 receptor expression. Hypertension 2019;74:967-74.

27. Nelson JF, Felicio LS, Randall PK, Sims C, Finch CE. A longitudinal study of estrous cyclicity in aging C57BL/6J mice: I. Cycle frequency, length and vaginal cytology. Biol Reprod 1982;27:327-39.

28. Kim SK, McCurley AT, DuPont JJ, et al. Smooth muscle cell-mineralocorticoid receptor as a mediator of cardiovascular stiffness with aging. Hypertension 2018;71:609-21.

29. DuPont JJ, McCurley A, Davel AP, et al. Vascular mineralocorticoid receptor regulates microRNA-155 to promote vasoconstriction and rising blood pressure with aging. JCI Insight 2016;1:e88942.

30. DuPont JJ, Ramick MG, Farquhar WB, Townsend RR, Edwards DG. NADPH oxidase-derived reactive oxygen species contribute to impaired cutaneous microvascular function in chronic kidney disease. Am J Physiol Renal Physiol 2014;306:F1499-506.

31. Dupont JJ, Farquhar WB, Townsend RR, Edwards DG. Ascorbic acid or L-arginine improves cutaneous microvascular function in chronic kidney disease. J Appl Physiol 2011;111:1561-7.

32. Turner CG, Stanhewicz AE, Nielsen KE, Otis JS, Feresin RG, Wong BJ. Effects of biological sex and oral contraceptive pill use on cutaneous microvascular endothelial function and nitric oxide-dependent vasodilation in humans. J Appl Physiol 2023;134:858-67.

33. Turner CG, Hayat MJ, Grosch C, Quyyumi AA, Otis JS, Wong BJ. Endothelin a receptor inhibition increases nitric oxide-dependent vasodilation independent of superoxide in non-hispanic black young adults. J Appl Physiol 2023;134:891-9.

34. Reckelhoff JF. Mechanisms of sex and gender differences in hypertension. J Hum Hypertens 2023;37:596-601.

35. Mishra JS, Kumar S. Activation of angiotensin type 2 receptor attenuates testosterone-induced hypertension and uterine vascular resistance in pregnant rats. Biol Reprod 2021;105:192-203.

36. Widdop RE, Jones ES, Hannan RE, Gaspari TA. Angiotensin AT2 receptors: cardiovascular hope or hype? Br J Pharmacol 2003;140:809-24.

37. González-Blázquez R, Alcalá M, Fernández-Alfonso MS, et al. C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT2, Mas and B2 receptors. Clin Sci 2021;135:1145-63.

38. Pinaud F, Bocquet A, Dumont O, et al. Paradoxical role of angiotensin II type 2 receptors in resistance arteries of old rats. Hypertension 2007;50:96-102.

39. Waheed N, Elias-Smale S, Malas W, et al. Sex differences in non-obstructive coronary artery disease. Cardiovasc Res 2020;116:829-40.

40. Toering TJ, van der Graaf AM, Visser FW, et al. Gender differences in response to acute and chronic angiotensin II infusion: a translational approach. Physiol Rep 2015;3:e12434.

41. Brown RD, Hilliard LM, Head GA, Jones ES, Widdop RE, Denton KM. Sex differences in the pressor and tubuloglomerular feedback response to angiotensin II. Hypertension 2012;59:129-35.

42. Sampson AK, Hilliard LM, Moritz KM, et al. The arterial depressor response to chronic low-dose angiotensin II infusion in female rats is estrogen dependent. Am J Physiol Regul Integr Comp Physiol 2012;302:R159-65.

43. Barsha G, Mirabito Colafella KM, Walton SL, et al. In aged females, the enhanced pressor response to angiotensin II is attenuated by estrogen replacement via an angiotensin type 2 receptor-mediated mechanism. Hypertension 2021;78:128-37.

44. Dai SY, Peng W, Zhang YP, Li JD, Shen Y, Sun XF. Brain endogenous angiotensin II receptor type 2 (AT2-R) protects against DOCA/salt-induced hypertension in female rats. J Neuroinflammation 2015;12:47.

45. Hilliard LM, Nematbakhsh M, Kett MM, et al. Gender differences in pressure-natriuresis and renal autoregulation: role of the Angiotensin type 2 receptor. Hypertension 2011;57:275-82.

46. Mirabito KM, Hilliard LM, Kett MM, et al. Sex- and age-related differences in the chronic pressure-natriuresis relationship: role of the angiotensin type 2 receptor. Am J Physiol Renal Physiol 2014;307:F901-7.

47. Manrique-Acevedo C, Chinnakotla B, Padilla J, Martinez-Lemus LA, Gozal D. Obesity and cardiovascular disease in women. Int J Obes 2020;44:1210-26.

48. Lum-Naihe K, Toedebusch R, Mahmood A, et al. Cardiovascular disease progression in female zucker diabetic fatty rats occurs via unique mechanisms compared to males. Sci Rep 2017;7:17823.

49. Belenchia AM, Boukhalfa A, DeMarco VG, et al. Cardiovascular protective effects of NP-6A4, a drug with the FDA designation for pediatric cardiomyopathy, in female rats with obesity and pre-diabetes. Cells 2023;12:1373.

50. Gavini MP, Mahmood A, Belenchia AM, et al. Suppression of inflammatory cardiac cytokine network in rats with untreated obesity and pre-diabetes by AT2 receptor agonist NP-6A4. Front Pharmacol 2021;12:693167.

51. Baiardi G, Macova M, Armando I, Ando H, Tyurmin D, Saavedra JM. Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat. Regul Pept 2005;124:7-17.

52. Macova M, Armando I, Zhou J, et al. Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats. Neuroendocrinology 2008;88:276-86.

53. Stewart JM, Taneja I, Raghunath N, Clarke D, Medow MS. Intradermal angiotensin II administration attenuates the local cutaneous vasodilator heating response. Am J Physiol Heart Circ Physiol 2008;295:H327-34.

54. Barsha G, Denton KM, Mirabito Colafella KM. Sex- and age-related differences in arterial pressure and albuminuria in mice. Biol Sex Differ 2016;7:57.

55. McCurley A, Pires PW, Bender SB, et al. Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nat Med 2012;18:1429-33.

The Journal of Cardiovascular Aging
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