REFERENCES
1. Nakada Y, Canseco DC, Thet S, et al. Hypoxia induces heart regeneration in adult mice. Nature 2017;541:222-7.
2. Puente BN, Kimura W, Muralidhar SA, et al. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell 2014;157:565-79.
3. Nguyen NUN, Canseco DC, Xiao F, et al. A calcineurin-Hoxb13 axis regulates growth mode of mammalian cardiomyocytes. Nature 2020;582:271-6.
4. McQuin C, Goodman A, Chernyshev V, et al. CellProfiler 3.0: next-generation image processing for biology. PLoS Biol 2018;16:e2005970.
5. Moslehi J, Minamishima YA, Shi J, et al. Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy. Circulation 2010;122:1004-16.
6. Ali SR, Hippenmeyer S, Saadat LV, Luo L, Weissman IL, Ardehali R. Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in mice. Proc Natl Acad Sci USA 2014;111:8850-5.
7. Scortegagna M, Ding K, Oktay Y, et al. Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice. Nat Genet 2003;35:331-40.
8. Smith J, Mun Tho L, Xu N, Gillespie DA. Chapter 3 - the ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. Adv Cancer Res 2010;108:73-112.
9. Nakada Y, Nhi Nguyen NU, Xiao F, et al. DNA damage response mediates pressure overload-induced cardiomyocyte hypertrophy. Circulation 2019;139:1237-9.
10. Kinner A, Wu W, Staudt C, Iliakis G. Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res 2008;36:5678-94.
11. Choudhury S, Huang AY, Kim J, et al. Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity. Nat Aging 2022;2:714-25.
12. Fan Q, Mao H, Angelini A, et al. Depletion of endothelial prolyl hydroxylase domain protein 2 and 3 promotes cardiomyocyte proliferation and prevents ventricular failure induced by myocardial infarction. Circulation 2019;140:440-2.
13. Batie M, Frost J, Frost M, Wilson JW, Schofield P, Rocha S. Hypoxia induces rapid changes to histone methylation and reprograms chromatin. Science 2019;363:1222-6.
14. Chakraborty AA, Laukka T, Myllykoski M, et al. Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate. Science 2019;363:1217-22.
15. Koeppen M, Lee JW, Seo SW, et al. Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury. Nat Commun 2018;9:816.
16. Wu JW, Hu H, Li D, Ma LK. Hypoxia-inducible factor 2-alpha-dependent induction of IL-6 protects the heart from ischemia/reperfusion injury. Aging 2021;13:3443-58.
17. Hölscher M, Silter M, Krull S, et al. Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury. J Biol Chem 2011;286:11185-94.
18. Pradeep SR, Lim ST, Thirunavukkarasu M, et al. Protective effect of cardiomyocyte-specific prolyl-4-hydroxylase 2 inhibition on ischemic injury in a mouse MI model. J Am Coll Surg 2022;235:240-54.
