REFERENCES

1. Rabinovich-Nikitin I, Lieberman B, Martino TA, Kirshenbaum LA. Circadian-regulated cell death in cardiovascular diseases. Circulation 2019;139:965-80.

2. Rabinovich-Nikitin I, Love M, Kirshenbaum LA. Intersection of autophagy regulation and circadian rhythms in the heart. Biochim Biophys Acta Mol Basis Dis 2022;1868:166354.

3. Sciarretta S, Maejima Y, Zablocki D, Sadoshima J. The role of autophagy in the heart. Annu Rev Physiol 2018;80:1-26.

4. Rabinovich-Nikitin I, Rasouli M, Reitz CJ, et al. Mitochondrial autophagy and cell survival is regulated by the circadian clock gene in cardiac myocytes during ischemic stress. Autophagy 2021;17:3794-812.

5. Wang EY, Gang H, Aviv Y, Dhingra R, Margulets V, Kirshenbaum LA. p53 mediates autophagy and cell death by a mechanism contingent on Bnip3. Hypertension 2013;62:70-7.

6. Cassidy LD, Narita M. Autophagy at the intersection of aging, senescence, and cancer. Mol Oncol 2022;16:3259-75.

7. Ito H, Negoro H, Kono J, et al. Effectiveness and safety of a mixture of nobiletin and tangeretin in nocturia patients: a randomized, placebo-controlled, double-blind, crossover study. J Clin Med 2023;12:2757.

8. Kim E, Kim YJ, Ji Z, et al. ROR activation by nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer. Cell Death Dis 2022;13:374.

9. Dusabimana T, Kim SR, Kim HJ, Park SW, Kim H. Nobiletin ameliorates hepatic ischemia and reperfusion injury through the activation of SIRT-1/FOXO3a-mediated autophagy and mitochondrial biogenesis. Exp Mol Med 2019;51:1-16.

10. Moon JY, Cho SK. Nobiletin induces protective autophagy accompanied by ER-stress mediated apoptosis in human gastric cancer SNU-16 cells. Molecules 2016;21:914.

11. Lee JM, Kim H, Baek SH. Unraveling the physiological roles of retinoic acid receptor-related orphan receptor α. Exp Mol Med 2021;53:1278-86.

12. Hariharan N, Zhai P, Sadoshima J. Oxidative stress stimulates autophagic flux during ischemia/reperfusion. Antioxid Redox Signal 2011;14:2179-90.

13. Cui H, Kong Y, Zhang H. Oxidative stress, mitochondrial dysfunction, and aging. J Signal Transduct 2012;2012:646354.

14. Katayama H, Kogure T, Mizushima N, Yoshimori T, Miyawaki A. A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery. Chem Biol 2011;18:1042-52.

15. Biala AK, Kirshenbaum LA. The interplay between cell death signaling pathways in the heart. Trends Cardiovasc Med 2014;24:325-31.

16. Kirshenbaum LA. Regulation of autophagy in the heart in health and disease. J Cardiovasc Pharmacol 2012;60:109.

17. Rubinsztein DC, Mariño G, Kroemer G. Autophagy and aging. Cell 2011;146:682-95.

18. Wang HH, Sun YN, Qu TQ, et al. Nobiletin prevents D-galactose-induced C2C12 cell aging by improving mitochondrial function. Int J Mol Sci 2022;23:11963.

19. Dhingra R, Kirshenbaum LA. Regulation of mitochondrial dynamics and cell fate. Circ J 2014;78:803-10.

20. Huang H, Li L, Shi W, et al. The multifunctional effects of nobiletin and its metabolites in vivo and in vitro. Evid Based Complement Alternat Med 2016;2016:2918796.