fig2

Figure 2. Chromosomal location-specific effect of POLG mutation on mt-tRNA expression as measured by RNA-Seq. Expression of clustered mt-tRNAs in WT and POLG mutant mice is presented in relation to location of encoding within the mitochondrial genome. A pattern of 4 local clusters of mt-tRNAs emerges where each mt-tRNA in the cluster shows similar changes in gene expression in response to POLG mutation (center depiction of mitochondrial chromosome derived in BioRender).