REFERENCES
2. Lodato MA, Vijg J. Editorial: somatic mutations, genome mosaicism and aging. Front Aging 2022;3:1115408.
3. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: an expanding universe. Cell 2023;186:243-78.
4. Choudhury S, Huang AY, Kim J, et al. Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity. Nat Aging 2022;2:714-25.
5. Dollé ME, Snyder WK, Gossen JA, Lohman PH, Vijg J. Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine. Proc Natl Acad Sci USA 2000;97:8403-8.
6. Kirillova A, Han L, Liu H, Kühn B. Polyploid cardiomyocytes: implications for heart regeneration. Development 2021;148:dev199401.
7. Abdellatif M, Rainer PP, Sedej S, Kroemer G. Hallmarks of cardiovascular ageing. Nat Rev Cardiol 2023 [Online ahead of print].
8. Szczepanowska K, Trifunovic A. Origins of mtDNA mutations in ageing. Essays Biochem 2017;61:325-37.
9. Sanchez-Contreras M, Sweetwyne MT, Tsantilas KA, et al. The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging. Elife 2023;12:e83395.