fig6

Figure 6. Left ventricular remodeling induced by mTAC. (A and B) Quantification of heart weight to body weight (HW/BW) (A) and heart weight to tibia length ratios (HW/TL) (B) in mTAC versus sham mice. Quantification of NPPA (C) and NPPB (D) mRNA expression in mTAC vs. sham hearts. (E) Masson trichrome staining of fibrosis in the whole heart (upper panels) and left ventricular histological sections (bottom panels) in sham (left panels) and mTAC mice (right panels). (F) Quantification of left ventricular fibrosis in sham and mTAC mice. Data shown mean ± SEM. *P < 0.05 and **P < 0.01 using student’s t-test.