fig1

Figure 1. A schematic summary for the paracrine crosstalk between myeloid and endothelial cells (ECs) for vascular repair of the injured heart. In response to myocardial infarction (MI), CCR2⁺ myeloid cells infiltrate the heart and secrete METRNL which binds to KIT tyrosine receptor expressed on a subset of cardiac ECs. The KIT-METRNL signaling cascade induces the proliferation and migration of KIT⁺ ECs, contributing to tissue repair.