fig1

Figure 1. Structures, predicted chemical properties, and mitophagy activating pathway of Spermidine and VL-004, described by Srivastava et al. “Log P” is the water octanol partitioning coefficient^[3]; “MR” is molar refractivity; “Henry’s law” is solubility constant; “Heat of form” (formation) is enthalpy; “tPSA” is topological polar surface area. Neither compound has any exception to Lipinski’s rule, suggesting that they both have pharmaceutical properties of orally active drugs.