REFERENCES

1. Housden BE, Muhar M, Gemberling M, et al. Loss-of-function genetic tools for animal models: cross-species and cross-platform differences. Nat Rev Genet 2017;18:24-40.

2. Rajewsky K, Gu H, Kühn R, et al. Conditional gene targeting. J Clin Invest 1996;98:600-3.

3. Frangogiannis NG. The inflammatory response in myocardial injury, repair, and remodelling. Nat Rev Cardiol 2014;11:255-65.

4. Vatner SF. Why So Few New Cardiovascular Drugs Translate to the Clinics. Circ Res 2016;119:714-7.

5. Ioannidis JP. Why most published research findings are false. PLoS Med 2005;2:e124.