fig8

Figure 8. Effects of suppression or activation of the β-catenin on myocardial fibrosis in 4-week-old mice. (A) Picrosirius red-stained thin myocardial sections in 4 weeks old wild type, Myh6-Mcm, β-catenin LoF and GoF hearts showing no change in myocardial fibrosis. (B) Quantitation of myocardial fibrosis presented as % collagen volume fraction (CVF) in the experimental groups (n = 5). (C) RT-PCR data showing transcript levels of genes involved in myocardial fibrosis in the β-catenin LoF and GoF hearts along with the control hearts (n = 5). Myh6-Mcm: Myosin heavy chain 6-MerCreMer; RT-PCR: reverse transcription-polymerase chain reaction; GoF: gain-of-function; LoF: loss-of-function.