REFERENCES
1. Hodge AJ, Zhong J, Lipke EA. Enhanced stem cell-derived cardiomyocyte differentiation in suspension culture by delivery of nitric oxide using S-nitrosocysteine. Biotechnol Bioeng 2016;113:882-94.
2. Wu B, Yu H, Wang Y, et al. Peroxiredoxin-2 nitrosylation facilitates cardiomyogenesis of mouse embryonic stem cells via XBP-1s/PI3K pathway. Free Radic Biol Med 2016;97:179-91.
3. Dulce RA, Mayo V, Rangel EB, Balkan W, Hare JM. Interaction between neuronal nitric oxide synthase signaling and temperature influences sarcoplasmic reticulum calcium leak: role of nitroso-redox balance. Circ Res 2015;116:46-55.
4. Haldar SM, Stamler JS. S-nitrosylation: integrator of cardiovascular performance and oxygen delivery. J Clin Invest 2013;123:101-10.
5. Cao Y, Gomes SA, Rangel EB, et al. S-nitrosoglutathione reductase-dependent PPARγ denitrosylation participates in MSC-derived adipogenesis and osteogenesis. J Clin Invest 2015;125:1679-91.
6. Beigi F, Gonzalez DR, Minhas KM, et al. Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function. Proc Natl Acad Sci U S A 2012;109:4314-9.
7. Chung HS, Murray CI, Venkatraman V, et al. Dual labeling biotin switch assay to reduce bias derived from different cysteine subpopulations: a method to maximize S-nitrosylation detection. Circ Res 2015;117:846-57.
8. Liu L, Yan Y, Zeng M, et al. Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. Cell 2004;116:617-28.
9. Hatzistergos KE, Paulino EC, Dulce RA, et al. S-nitrosoglutathione reductase deficiency enhances the proliferative expansion of adult heart progenitors and myocytes post myocardial infarction. J Am Heart Assoc 2015;4:e001974.
10. Ohta S, Suzuki K, Tachibana K, Tanaka H, Yamada G. Cessation of gastrulation is mediated by suppression of epithelial-mesenchymal transition at the ventral ectodermal ridge. Development 2007;134:4315-24.
11. Thiery JP, Sleeman JP. Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 2006;7:131-42.
12. Zhou BP, Deng J, Xia W, et al. Dual regulation of snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol 2004;6:931-40.
13. Burridge PW, Matsa E, Shukla P, et al. Chemically defined generation of human cardiomyocytes. Nat Methods 2014;11:855-60.
14. Kattman SJ, Witty AD, Gagliardi M, et al. Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell 2011;8:228-40.
15. Wang SB, Venkatraman V, Crowgey EL, et al. Protein S-nitrosylation controls glycogen synthase Kinase 3β function independent of its phosphorylation state. Circ Res 2018;122:1517-31.
16. Uosaki H, Magadum A, Seo K, et al. Identification of chemicals inducing cardiomyocyte proliferation in developmental stage-specific manner with pluripotent stem cells. Circ Cardiovasc Genet 2013;6:624-33.
18. Lian X, Hsiao C, Wilson G, et al. Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc Natl Acad Sci U S A 2012;109:E1848-57.
19. Forrester MT, Thompson JW, Foster MW, Nogueira L, Moseley MA, Stamler JS. Proteomic analysis of S-nitrosylation and denitrosylation by resin-assisted capture. Nat Biotechnol 2009;27:557-9.
20. Bloch W, Fleischmann BK, Lorke DE, et al. Nitric oxide synthase expression and role during cardiomyogenesis. Cardiovasc Res 1999;3:675-84.
21. Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861-72.
22. Li HX, Han M, Bernier M, et al. Krüppel-like factor 4 promotes differentiation by transforming growth factor-beta receptor-mediated Smad and p38 MAPK signaling in vascular smooth muscle cells. J Biol Chem 2010;285:17846-56.
23. Tejedo JR, Tapia-Limonchi R, Mora-Castilla S, et al. Low concentrations of nitric oxide delay the differentiation of embryonic stem cells and promote their survival. Cell Death Dis 2010;1:e80.
24. Saraiva RM, Minhas KM, Raju SV, et al. Deficiency of neuronal nitric oxide synthase increases mortality and cardiac remodeling after myocardial infarction: role of nitroso-redox equilibrium. Circulation 2005;112:3415-22.
25. Fu K, Chronis C, Soufi A, et al. Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPSC reprogramming. BMC Genomics 2018;19:956.
26. Bachelder RE, Yoon SO, Franci C, de Herreros AG, Mercurio AM. Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition. J Cell Biol 2005;168:29-33.
27. Wang Y, Liu J, Ying X, Lin PC, Zhou BP. Twist-mediated epithelial-mesenchymal transition promotes breast tumor cell invasion via inhibition of hippo pathway. Sci Rep 2016;6:24606.
28. Otani R, Mukasa A, Shin M, et al. Brachyury gene copy number gain and activation of the PI3K/Akt pathway: association with upregulation of oncogenic Brachyury expression in skull base chordoma. J Neurosurg 2018;128:1428-37.
29. Yan X, Li Z, Li H, et al. Inhibition of glycogen synthase kinase 3 beta suppresses the growth and survival of skull base chordoma cells by downregulating brachyury expression. Onco Targets Ther 2019;12:9783-91.
30. Zhu J, Kwan KM, Mackem S. Putative oncogene brachyury (T) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMT. Proc Natl Acad Sci U S A 2016;113:3820-5.
31. Bedada FB, Chan SS, Metzger SK, et al. Acquisition of a quantitative, stoichiometrically conserved ratiometric marker of maturation status in stem cell-derived cardiac myocytes. Stem Cell Reports 2014;3:594-605.
32. Weber N, Schwanke K, Greten S, et al. Stiff matrix induces switch to pure β-cardiac myosin heavy chain expression in human ESC-derived cardiomyocytes. Basic Res Cardiol 2016;111:68.
33. Mesaeli N, Nakamura K, Zvaritch E, et al. Calreticulin is essential for cardiac development. J Cell Biol 1999;144:857-68.
34. Li J, Pucéat M, Perez-Terzic C, et al. Calreticulin reveals a critical Ca(2+) checkpoint in cardiac myofibrillogenesis. J Cell Biol 2002;158:103-13.
35. Mora-Castilla S, Tejedo JR, Hmadcha A, et al. Nitric oxide repression of Nanog promotes mouse embryonic stem cell differentiation. Cell Death Differ 2010;17:1025-33.
36. Benhar M, Forrester MT, Stamler JS. Protein denitrosylation: enzymatic mechanisms and cellular functions. Nat Rev Mol Cell Biol 2009;10:721-32.
37. Kohr MJ, Aponte AM, Sun J, et al. Characterization of potential S-nitrosylation sites in the myocardium. Am J Physiol Heart Circ Physiol 2011;300:H1327-35.
38. Lickert H, Kutsch S, Kanzler B, Tamai Y, Taketo MM, Kemler R. Formation of multiple hearts in mice following deletion of β-catenin in the embryonic endoderm. Dev Cell 2002;3:171-81.
39. Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 2004;10:55-63.
40. McCubrey JA, Steelman LS, Bertrand FE, et al. GSK-3 as potential target for therapeutic intervention in cancer. Oncotarget 2014;5:2881-911.
41. Nakamura M, Liu T, Husain S, et al. Glycogen Synthase kinase-3α promotes fatty acid uptake and lipotoxic cardiomyopathy. Cell Metab 2019;29:1119-1134.e12.
42. Hödar C, Assar R, Colombres M, et al. Genome-wide identification of new Wnt/beta-catenin target genes in the human genome using CART method. BMC Genomics 2010;11:348.
43. Huang TS, Li L, Moalim-Nour L, et al. A regulatory network involving β-catenin, e-cadherin, PI3k/Akt, and slug balances self-renewal and differentiation of human pluripotent stem cells in response to wnt signaling. Stem Cells 2015;33:1419-33.
44. Baritaki S, Huerta-Yepez S, Sahakyan A, et al. Mechanisms of nitric oxide-mediated inhibition of EMT in cancer: inhibition of the metastasis-inducer Snail and induction of the metastasis-suppressor RKIP. Cell Cycle 2010;9:4931-40.
45. Mirzoev TM, Sharlo KA, Shenkman BS. The role of GSK-3β in the regulation of protein turnover, myosin phenotype, and oxidative capacity in skeletal muscle under disuse conditions. Int J Mol Sci 2021;22:5081.
46. Woulfe KC, Gao E, Lal H, et al. Glycogen synthase kinase-3beta regulates post-myocardial infarction remodeling and stress-induced cardiomyocyte proliferation in vivo. Circ Res 2010;106:1635-45.
47. Matsuda T, Zhai P, Maejima Y, et al. Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload. Proc Natl Acad Sci U S A 2008;105:20900-5.
48. Singh AP, Umbarkar P, Guo Y, Force T, Gupte M, Lal H. Inhibition of GSK-3 to induce cardiomyocyte proliferation: a recipe for in situ cardiac regeneration. Cardiovasc Res 2019;115:20-30.
49. Jho EH, Zhang T, Domon C, Joo CK, Freund JN, Costantini F. Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol 2002;22:1172-83.
50. Kang HE, Seo Y, Yun JS, et al. Metformin and niclosamide synergistically suppress Wnt and YAP in APC-mutated colorectal cancer. Cancers (Basel) 2021;13:3437.
51. Ahn SY, Kim NH, Lee K, et al. Niclosamide is a potential therapeutic for familial adenomatosis polyposis by disrupting Axin-GSK3 interaction. Oncotarget 2017;8:31842-55.
52. Ding VW, Chen RH, McCormick F. Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling. J Biol Chem 2000;275:32475-81.
53. Lui TT, Lacroix C, Ahmed SM, et al. The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling. Mol Cell Biol 2011;31:2053-65.
54. Kehat I, Kenyagin-Karsenti D, Snir M, et al. Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J Clin Invest 2001;108:407-14.
55. Weinberger F, Mehrkens D, Friedrich FW, et al. Localization of Islet-1-positive cells in the healthy and infarcted adult murine heart. Circ Res 2012;110:1303-10.
56. Kunieda T, Minamino T, Miura K, et al. Reduced nitric oxide causes age-associated impairment of circadian rhythmicity. Circ Res 2008;102:607-14.
57. Murray CI, Kane LA, Uhrigshardt H, Wang SB, Van Eyk JE. Site-mapping of in vitro S-nitrosation in cardiac mitochondria: implications for cardioprotection. Mol Cell Proteomics 2011;10:M110.004721.
58. Gonzalez DR, Treuer A, Sun QA, Stamler JS, Hare JM. S-nitrosylation of cardiac ion channels. J Cardiovasc Pharmacol 2009;54:188-95.
59. Petroff MG, Kim SH, Pepe S, et al. Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes. Nat Cell Biol 2001;3:867-73.
60. Xu L, Eu JP, Meissner G, Stamler JS. Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation. Science 1998;279:234-7.
61. Gonzalez DR, Beigi F, Treuer AV, Hare JM. Deficient ryanodine receptor S-nitrosylation increases sarcoplasmic reticulum calcium leak and arrhythmogenesis in cardiomyocytes. Proc Natl Acad Sci U S A 2007;104:20612-7.
62. Ahmed RE, Anzai T, Chanthra N, Uosaki H. A brief review of current maturation methods for human induced pluripotent stem cells-derived cardiomyocytes. Front Cell Dev Biol 2020;8:178.
63. Acun A, Nguyen TD, Zorlutuna P. In vitro aged, hiPSC-origin engineered heart tissue models with age-dependent functional deterioration to study myocardial infarction. Acta Biomater 2019;94:372-91.
