REFERENCES
1. Chang C, Yan J, Yao Z, Zhang C, Li X, Mao HQ. Effects of mesenchymal stem cell-derived paracrine signals and their delivery strategies. Adv Healthc Mater. 2021;10:e2001689.
2. Trigo CM, Rodrigues JS, Camões SP, Solá S, Miranda JP. Mesenchymal stem cell secretome for regenerative medicine: where do we stand? J Adv Res 2025;70:103-24.
3. Mahdavi-Jouibari F, Parseh B, Kazeminejad E, Khosravi A. Hopes and opportunities of stem cells from human exfoliated deciduous teeth (SHED) in cartilage tissue regeneration. Front Bioeng Biotechnol. 2023;11:1021024.
4. Kunimatsu R, Hiraki T, Rikitake K, et al. Effects of human deciduous dental pulp-derived mesenchymal stem cell-derived conditioned medium on the metabolism of HUVECs, osteoblasts, and BMSCs. Cells. 2022;11:3222.
5. Rogulska O, Vackova I, Prazak S, et al. Storage conditions affect the composition of the lyophilized secretome of multipotent mesenchymal stromal cells. Sci Rep. 2024;14:10243.
6. Chouaib B, Haack-Sørensen M, Chaubron F, Cuisinier F, Collart-Dutilleul PY. Towards the standardization of mesenchymal stem cell secretome-derived product manufacturing for tissue regeneration. Int J Mol Sci. 2023;24:12594.
7. Gao Y, Sang J, Wan Z, et al. Advanced small extracellular vesicles delivery systems for in situ tissue engineering. Extracell Vesicles Circ Nucl Acids. 2026;7:354-76.
8. Welsh JA, Goberdhan DCI, O'Driscoll L, et al. ; MISEV Consortium. Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches. J Extracell Vesicles. 2024;13:e12404.
9. Wu J, Chen L, Wang R, et al. Exosomes secreted by stem cells from human exfoliated deciduous teeth promote alveolar bone defect repair through the regulation of angiogenesis and osteogenesis. ACS Biomater Sci Eng. 2019;5:3561-71.
10. Gao Y, Yuan Z, Yuan X, et al. Bioinspired porous microspheres for sustained hypoxic exosomes release and vascularized bone regeneration. Bioact Mater. 2022;14:377-88.
11. Xie Y, Yu L, Cheng Z, et al. SHED-derived exosomes promote LPS-induced wound healing with less itching by stimulating macrophage autophagy. J Nanobiotechnology. 2022;20:239.
12. Jin S, Wang Y, Wu X, et al. Young exosome bio-nanoparticles restore aging-impaired tendon stem/progenitor cell function and reparative capacity. Adv Mater. 2023;35:e2211602.
13. Long R, Wang S. Exosomes from preconditioned mesenchymal stem cells: tissue repair and regeneration. Regen Ther. 2024;25:355-66.
14. Ma M. Role of hypoxia in mesenchymal stem cells from dental pulp: influence, mechanism and application. Cell Biochem Biophys. 2024;82:535-47.
15. Siavashi V, Nassiri SM, Farhadi Mahalli M, Kamarul T, Sharifi AM. Elucidating the effect of deferoxamine, a hypoxia mimetic agent, on angiogenesis restoration in endothelial progenitor cells (EPCs) from diabetic mice. Iran J Basic Med Sci. 2025;28:1589-97.
16. Song YC, Park GT, Moon HJ, et al. Hybrid spheroids containing mesenchymal stem cells promote therapeutic angiogenesis by increasing engraftment of co-transplanted endothelial colony-forming cells in vivo. Stem Cell Res Ther. 2023;14:193.
17. Liu P, Qin L, Liu C, et al. Exosomes derived from hypoxia-conditioned stem cells of human deciduous exfoliated teeth enhance angiogenesis via the transfer of let-7f-5p and miR-210-3p. Front Cell Dev Biol. 2022;10:879877.
18. Zhu Y, Liao ZF, Mo MH, Xiong XD. Mesenchymal stromal cell-derived extracellular vesicles for vasculopathies and angiogenesis: therapeutic applications and optimization. Biomolecules. 2023;13:1109.
19. Du W, Zhang K, Zhang S, et al. Enhanced proangiogenic potential of mesenchymal stem cell-derived exosomes stimulated by a nitric oxide releasing polymer. Biomaterials. 2017;133:70-81.
20. Huang D, Shen H, Xie F, et al. Role of mesenchymal stem cell-derived exosomes in the regeneration of different tissues. J Biol Eng. 2024;18:36.
21. Ratajczak J, Miekus K, Kucia M, et al. Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia. 2006;20:847-56.
22. Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9:654-9.
23. Huang K, Mi B, Xiong Y, et al. Angiogenesis during diabetic wound repair: from mechanism to therapy opportunity. Burns Trauma. 2025;13:tkae052.
24. Yi C, Wu W, Zheng D, et al. Targeted inhibition of endothelial calpain delays wound healing by reducing inflammation and angiogenesis. Cell Death Dis. 2020;11:533.
25. Galiano RD, Tepper OM, Pelo CR, et al. Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells. Am J Pathol. 2004;164:1935-47.
26. Sharifiaghdam M, Shaabani E, Faridi-Majidi R, De Smedt SC, Braeckmans K, Fraire JC. Macrophages as a therapeutic target to promote diabetic wound healing. Mol Ther. 2022;30:2891-908.
27. Peña OA, Martin P. Cellular and molecular mechanisms of skin wound healing. Nat Rev Mol Cell Biol. 2024;25:599-616.
28. Wetzler C, Kämpfer H, Stallmeyer B, Pfeilschifter J, Frank S. Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repair. J Invest Dermatol. 2000;115:245-53.




