REFERENCES

1. Matsuzaka Y, Yashiro R. Extracellular vesicles as novel drug-delivery systems through intracellular communications. Membranes. 2022;12:550.

2. Sharma S, Masud MK, Kaneti YV, et al. Extracellular vesicle nanoarchitectonics for novel drug delivery applications. Small. 2021;17:e2102220.

3. Jiang L, Vader P, Schiffelers RM. Extracellular vesicles for nucleic acid delivery: progress and prospects for safe RNA-based gene therapy. Gene Ther. 2017;24:157-66.

4. Kim HI, Park J, Zhu Y, Wang X, Han Y, Zhang D. Recent advances in extracellular vesicles for therapeutic cargo delivery. Exp Mol Med. 2024;56:836-49.

5. Xu G, Jin J, Fu Z, et al. Extracellular vesicle-based drug overview: research landscape, quality control and nonclinical evaluation strategies. Signal Transduct Target Ther. 2025;10:255.

6. Lundy DJ, Chau ZL, Chen SY, et al. Beyond extracellular vesicle (EV) hype: practical solutions and remaining hurdles in EV research, manufacturing, and clinical translation. Adv Sci. 2026;13:e21913.

7. Zhang J, Pan Y, She P, Rao L. From bench to bedside: the promise and roadblocks of extracellular vesicle therapeutics. Theranostics. 2026;16:5044-64.

8. Wang Y, Zhao K, Shi X, et al. Plant-derived extracellular nanovesicles for disease therapy. In: Wang Q, Zheng L, Editors. Extracellular vesicles. Singapore: Springer Nature; 2024. pp. 489-511.

9. Alzahrani FA, Khan MI, Kameli N, Alsahafi E, Riza YM. Plant-derived extracellular vesicles and their exciting potential as the future of next-generation drug delivery. Biomolecules. 2023;13:839.

10. Kang SJ, Rhee WJ. Engineered plant-derived extracellular vesicles as targeted drug carriers in cancer therapy. ACS Appl Bio Mater. 2026;9:1053-63.

11. Yazdanpanah S, Romano S, Valentino A, Galderisi U, Peluso G, Calarco A. Plant-derived exosomes: carriers and cargo of natural bioactive compounds: emerging functions and applications in human health. Nanomaterials. 2025;15:1005.

12. Tan F, Liu W, Li T, et al. Plant-derived extracellular vesicles as tools and targets for inflammatory diseases. J Nanobiotechnology. 2026;24:397.

13. Zuo Y, Zhang J, Sun B, et al. A new perspective on regenerative medicine: plant-derived extracellular vesicles. Biomolecules. 2025;15:1095.

14. Zhang J, Tian S, Guo L, Zhao H, Mao Z, Miao M. Chinese herbal medicine-derived extracellular vesicles as novel biotherapeutic tools: present and future. J Transl Med. 2024;22:1059.

15. Chen BB, Wang Y, Li YN, et al. Neuroprotective effects of Salvia Miltiorrhiza-derived extracellular nanovesicles in traumatic brain injury. J Neurotrauma. 2026;43:295-316.

16. Wu J, Chen X, Lin X, et al. Protective effects of Panax notoginseng saponins on cerebral ischemia/reperfusion injury: insights into SIRT1/NRF2/HO-1 pathway activation. Physiol Res. 2025;74:313-26.

17. Qu J, Xu N, Zhang J, Geng X, Zhang R. Panax notoginseng saponins and their applications in nervous system disorders: a narrative review. Ann Transl Med. 2020;8:1525.

18. Zhao C, Fu J, Wang Y, Zhou Y. Latest evidence and perspectives of Panax notoginseng extracts and preparations for the treatment of cardiovascular diseases. J Cardiovasc Pharmacol. 2025;85:248-60.

19. Peng M, Yi YX, Zhang T, Ding Y, Le J. Stereoisomers of saponins in Panax notoginseng (Sanqi): a review. Front Pharmacol. 2018;9:188.

20. Yang X, Yi R, Tian Y, et al. Effects of stem cell exosomes and sanqi-derived exosome-like nanoparticles on oxidative stress in skin cells. J Clin Med Images Case Rep. 2025;5:1797. Available from https://www.researchgate.net/publication/395391298_Effects_of_stem_cell_exosomes_and_sanqi-derived_exosome-like_nanoparticles_on_oxidative_stress_in_skin_cells [accessed 16 October 2026].

21. Li S, Zhang R, Wang A, et al. Panax notoginseng: derived exosome-like nanoparticles attenuate ischemia reperfusion injury via altering microglia polarization. J Nanobiotechnology. 2023;21:416.

22. Feigin VL, Brainin M, Norrving B, et al. World stroke organization: global stroke fact sheet 2025. Int J Stroke. 2025;20:132-44.

23. GBD 2019 Stroke Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol. 2021;20:795-820.

24. Lee TH. Intracerebral hemorrhage. Cerebrovasc Dis Extra. 2025;15:1-8.

25. O’Carroll CB, Brown BL, Freeman WD. Intracerebral hemorrhage: a common yet disproportionately deadly stroke subtype. Mayo Clin Proc. 2021;96:1639-54.

26. Gong Y, Li H, Cui H, Gong Y. Microglial mechanisms and therapeutic potential in brain injury post-intracerebral hemorrhage. J Inflamm Res. 2025;18:2955-73.

27. Huang Q, Yu X, Fu P, et al. Mechanisms and therapeutic targets of mitophagy after intracerebral hemorrhage. Heliyon. 2024;10:e23941.

28. Chen W, Guo C, Huang S, et al. MitoQ attenuates brain damage by polarizing microglia towards the M2 phenotype through inhibition of the NLRP3 inflammasome after ICH. Pharmacol Res. 2020;161:105122.

29. Chen T, Gao X, Chang Y, et al. Mitochondrial dysfunction in intracerebral hemorrhage: molecular mechanisms and pathological consequences. Front Cell Neurosci. 2026;20:1913984.

30. Yin R, Qiu C, Shen Q, Wang Z. Corin inhibits microglial inflammatory activation by suppressing mitochondrial dysfunction in intracerebral hemorrhage. BMB Rep. 2026;59:143-50.

31. Liu M, Li B, Yin Z, et al. Targeting mitochondrial dynamics: a promising approach for intracerebral hemorrhage therapy. Life Sci. 2025;361:123317.

32. Reddy PH, Reddy TP, Manczak M, Calkins MJ, Shirendeb U, Mao P. Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases. Brain Res Rev. 2011;67:103-18.

33. Shi W, Tan C, Liu C, Chen D. Mitochondrial fission mediated by Drp1-Fis1 pathway and neurodegenerative diseases. Rev Neurosci. 2023;34:275-94.

34. Qi X, Qvit N, Su YC, Mochly-Rosen D. A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J Cell Sci. 2013;126:789-802.

35. Liu W, Su C, Qi Y, Liang J, Zhao L, Shi Y. Brain-targeted heptapeptide-loaded exosomes attenuated ischemia-reperfusion injury by promoting the transfer of healthy mitochondria from astrocytes to neurons. J Nanobiotechnology. 2022;20:242.

36. Shang T, Kuang B, Zheng L, et al. Mitochondrial quality control: insights into intracerebral hemorrhage. Cell Mol Neurobiol. 2025;45:79.

37. Wang M, Wang W, Chopp M, Zhang ZG, Zhang Y. Therapeutic and diagnostic potential of extracellular vesicle (EV)-mediated intercellular transfer of mitochondria and mitochondrial components. J Cereb Blood Flow Metab. 2026;46:289-305.

38. Manickam DS, Pinky PP, Khare P. Extracellular vesicle-mediated mitochondria delivery: Premise and promise. J Cereb Blood Flow Metab. 2026;46:306-21.

Extracellular Vesicles and Circulating Nucleic Acids
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