REFERENCES
1. Chen B, Yu P, Chan WN, et al. Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets. Signal Transduct Target Ther. 2024;9:6.
2. Camp OG, Bembenek JN, Goud PT, Awonuga AO, Abu-Soud HM. The implications of insufficient zinc on the generation of oxidative stress leading to decreased oocyte quality. Reprod Sci. 2023;30:2069-78.
3. Brito S, Heo H, Kim J, et al. Age-associated interplay between zinc deficiency and Golgi stress hinders microtubule-dependent cellular signaling and epigenetic control. Dev Cell. 2025;60:1304-20.e7.
4. Vu TT, Fredenburgh JC, Weitz JI. Zinc: an important cofactor in haemostasis and thrombosis. Thromb Haemost. 2013;109:421-30.
5. Mammadova-Bach E, Braun A. Zinc homeostasis in platelet-related diseases. Int J Mol Sci. 2019;20:5258.
6. Zhu T, Ubhayasekera W, Nickolaus N, et al. Zinc ions bind to and inhibit activated protein C. Thromb Haemost. 2010;104:544-53.
7. Sen P, Sahoo S, Pendurthi UR, Rao LV. Zinc modulates the interaction of protein C and activated protein C with endothelial cell protein C receptor. J Biol Chem. 2010;285:20410-20.
8. Fatah K, Hessel B. Effect of zinc ions on fibrin network structure. Blood Coagul Fibrinolysis. 1998;9:629-35.
9. Watson BR, White NA, Taylor KA, et al. Zinc is a transmembrane agonist that induces platelet activation in a tyrosine phosphorylation-dependent manner. Metallomics. 2016;8:91-100.
10. Huo YN, Ekholm J, Hanahan DJ. A preferential inhibition by Zn2+ on platelet activating factor- and thrombin-induced serotonin secretion from washed rabbit platelets. Arch Biochem Biophys. 1988;260:841-6.
11. Majidi RF, Mesgar AS, Milan PB. Surface-modified, zinc-incorporated mesoporous silica nanoparticles with improved antibacterial and rapid hemostatic properties. Colloids Surf B Biointerfaces. 2024;243:114132.
12. Liao X, Ji P, Chi K, et al. Enhanced inhibition of protein disulfide isomerase and anti-thrombotic activity of a rutin derivative: rutin:Zn complex. RSC Adv. 2023;13:11464-71.
13. Ma L, Li Y, Peng J, et al. Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration. Cell Res. 2015;25:24-38.
14. Huang Y, Zucker B, Zhang S, et al. Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains. Nat Cell Biol. 2019;21:991-1002.
15. Jiang D, Jiao L, Li Q, et al. Neutrophil-derived migrasomes are an essential part of the coagulation system. Nat Cell Biol. 2024;26:1110-23.
16. Li A, Yang C, Zhang L. Zinc oxide nanoparticles promote migrasomes formation. J Hazard Mater. 2025;490:137792.
17. Andrew D, Gail R, Morag B, Kishor R. Recommended reference intervals for copper and zinc in serum using the US National Health and Nutrition Examination surveys (NHANES) data. Clin Chim Acta. 2023;546:117397.
18. Devarshi PP, Mao Q, Grant RW, Hazels Mitmesser S. Comparative absorption and bioavailability of various chemical forms of zinc in humans: a narrative review. Nutrients. 2024;16:4269.
20. Zhou Y, Feng M, Zhang L. Repurposing disulfiram: an innovative inhibitory approach against a broad spectrum of viruses. Biochem Biophys Res Commun. 2025;782:152596.
21. Zhou Y, Huang G, Liu M, Zhang M, Wu B, Gu J. SLC30 (ZnT) and SLC39 (ZIP) zinc transporter families: from gatekeepers of zinc homeostasis to promoters of tumorigenesis and targets for clinical therapy. Front Immunol. 2025;16:1750534.
22. Hou Y, Li A, Zhang S, Zhao M, Zhang L. Dietary zinc ions inhibit virus-induced migrasome formation, potentially reducing viral transmission. J Infect. 2026;92:106685.
23. Ding T, Ji J, Zhang W, et al. The phosphatidylinositol (4,5)-bisphosphate-Rab35 axis regulates migrasome formation. Cell Res. 2023;33:617-27.
24. Zhang N, Gao S, Zhang L. Chikungunya virus nsP1 induces migrasome formation. J Infect. 2022;85:e158-61.
25. Lu P, Liu R, Lu D, et al. Chemical screening identifies ROCK1 as a regulator of migrasome formation. Cell Discov. 2020;6:51.
26. Wu Z, Gao D, Găman MA, Prabahar K, Kord-Varkaneh H, Yang Y. Association of dietary zinc intake with hs-CRP and the lipid profile: evidence from the 2017-2020 National Health and Nutrition Examination Survey (NHANES). J Public Health Policy. 2026;47:361-74.
27. Loaiza-Giraldo JP, Amigo-Fierro F, Cancino-Castro CI, et al. Effects of zinc supplementation on glycemic control, insulin resistance, inflammation and oxidative stress in diabetes: a systematic review and meta-analysis of randomized controlled trials. Endocrinol Diabetes Metab. 2026;9:e70264.
28. Fowler DM, Cooper SJ, Stephany JJ, Hendon N, Nelson S, Fields S. Suppression of statin effectiveness by copper and zinc in yeast and human cells. Mol Biosyst. 2011;7:533-44.
29. Würtz P, Wang Q, Soininen P, et al. Metabolomic profiling of statin use and genetic inhibition of HMG-CoA reductase. J Am Coll Cardiol. 2016;67:1200-10.
30. Coupland CA, Naylor-Adamson L, Booth Z, et al. Platelet zinc status regulates prostaglandin-induced signaling, altering thrombus formation. J Thromb Haemost. 2023;21:2545-58.
31. Kuravi SJ, Ahmed NS, Taylor KA, et al. Delineating zinc influx mechanisms during platelet activation. Int J Mol Sci. 2023;24:11689.
32. Prasad AS, Rabbani P, Abbasii A, Bowersox E, Fox MR. Experimental zinc deficiency in humans. Ann Intern Med. 1978;89:483-90.
33. Gordon PR, Woodruff CW, Anderson HL, O’Dell BL. Effect of acute zinc deprivation on plasma zinc and platelet aggregation in adult males. Am J Clin Nutr. 1982;35:113-9.




