REFERENCES

1. Liu YJ, Wang C. A review of the regulatory mechanisms of extracellular vesicles-mediated intercellular communication. Cell Commun Signal. 2023;21:77.

2. Yu J, Sane S, Kim JE, et al. Biogenesis and delivery of extracellular vesicles: harnessing the power of EVs for diagnostics and therapeutics. Front Mol Biosci. 2023;10:1330400.

3. Brodeur A, Migneault F, Lanoie M, et al. Apoptotic exosome-like vesicles transfer specific and functional mRNAs to endothelial cells by phosphatidylserine-dependent macropinocytosis. Cell Death Dis. 2023;14:449.

4. Beillevaire D, Migneault F, Turgeon J, et al. Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes. Cell Death Dis. 2022;13:145.

5. Ciardiello C, Migliorino R, Leone A, Budillon A. Large extracellular vesicles: size matters in tumor progression. Cytokine Growth Factor Rev. 2020;51:69-74.

6. Welsh JA, Goberdhan DCI, O’Driscoll L, et al; MISEV Consortium. Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches. J Extracell Vesicles. 2024;13:e12404.

7. Tian T, Wang Y, Wang H, Zhu Z, Xiao Z. Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy. J Cell Biochem. 2010;111:488-96.

8. Parolini I, Federici C, Raggi C, et al. Microenvironmental pH is a key factor for exosome traffic in tumor cells. J Biol Chem. 2009;284:34211-22.

9. Raposo G, Nijman HW, Stoorvogel W, et al. B lymphocytes secrete antigen-presenting vesicles. J Exp Med. 1996;183:1161-72.

10. Kwok ZH, Wang C, Jin Y. Extracellular vesicle transportation and uptake by recipient cells: a critical process to regulate human diseases. Processes. 2021;9:273.

11. Ribovski L, Joshi B, Gao J, Zuhorn I. Breaking free: endocytosis and endosomal escape of extracellular vesicles. Extracell Vesicles Circ Nucl Acids. 2023;4:283-305.

12. Xie S, Zhang Q, Jiang L. Current knowledge on exosome biogenesis, cargo-sorting mechanism and therapeutic implications. Membranes. 2022;12:498.

13. Wang Y, Liu J, Burrows PD, Wang J. B cell development and maturation. Adv Exp Med Biol. 2020;1254:1-22.

14. Denzer K, van Eijk M, Kleijmeer MJ, Jakobson E, de Groot C, Geuze HJ. Follicular dendritic cells carry MHC class II-expressing microvesicles at their surface. J Immunol. 2000;165:1259-65.

15. Yim KHW, Al Hrout A, Chahwan R. Intercellular epigenomic signalling via extracellular vesicles during B cell maturation. J Extracell Vesicles. 2025;14:e70040.

16. Admyre C, Telemo E, Almqvist N, et al. Exosomes - nanovesicles with possible roles in allergic inflammation. Allergy. 2008;63:404-8.

17. Phan HD, Longjohn MN, Gormley DJB, et al. CD24 and IgM stimulation of B cells triggers transfer of functional B cell receptor to B cell recipients via extracellular vesicles. J Immunol. 2021;207:3004-15.

18. Ayre DC, Elstner M, Smith NC, Moores ES, Hogan AM, Christian SL. Dynamic regulation of CD24 expression and release of CD24-containing microvesicles in immature B cells in response to CD24 engagement. Immunology. 2015;146:217-33.

19. Fernández-Messina L, Rodríguez-Galán A, de Yébenes VG, et al. Transfer of extracellular vesicle-microRNA controls germinal center reaction and antibody production. EMBO Rep. 2020;21:e48925.

20. Yang J, Dang G, Lü S, et al. T-cell-derived extracellular vesicles regulate B-cell IgG production via pyruvate kinase muscle isozyme 2. FASEB J. 2019;33:12780-99.

21. Adamo A, Brandi J, Caligola S, et al. Extracellular vesicles mediate mesenchymal stromal cell-dependent regulation of B Cell PI3K-AKT signaling pathway and actin cytoskeleton. Front Immunol. 2019;10:446.

22. Wang J, Hendrix A, Hernot S, et al. Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells. Blood. 2014;124:555-66.

23. Smallwood DT, Apollonio B, Willimott S, et al. Extracellular vesicles released by CD40/IL-4-stimulated CLL cells confer altered functional properties to CD4+ T cells. Blood. 2016;128:542-52.

24. Chen Z, You L, Wang L, et al. Dual effect of DLBCL-derived EXOs in lymphoma to improve DC vaccine efficacy in vitro while favor tumorgenesis in vivo. J Exp Clin Cancer Res. 2018;37:190.

25. Liu W, Zhu M, Wang H, Wang W, Lu Y. Diffuse large B cell lymphoma-derived extracellular vesicles educate macrophages to promote tumours progression by increasing PGC-1β. Scand J Immunol. 2020;91:e12841.

26. Uziel O, Lipshtein L, Sarsor Z, et al. Chronic lymphocytic leukemia (CLL)-derived extracellular vesicles educate endothelial cells to become IL-6-producing, CLL-supportive cells. Biomedicines. 2024;12:1381.

27. Paggetti J, Haderk F, Seiffert M, et al. Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts. Blood. 2015;126:1106-17.

28. Liu Z, Liu H, Li Y, et al. Multiple myeloma-derived exosomes inhibit osteoblastic differentiation and improve IL-6 secretion of BMSCs from multiple myeloma. J Investig Med. 2020;68:45-51.

29. Zhang L, Zhou S, Zhou T, Li X, Tang J. Potential of the tumor‑derived extracellular vesicles carrying the miR‑125b‑5p target TNFAIP3 in reducing the sensitivity of diffuse large B cell lymphoma to rituximab. Int J Oncol. 2021;58:31.

30. Feng Y, Zhong M, Tang Y, et al. The role and underlying mechanism of exosomal CA1 in chemotherapy resistance in diffuse large B cell lymphoma. Mol Ther Nucleic Acids. 2020;21:452-63.

31. Lee-Chang C, Rashidi A, Miska J, et al. Myeloid-derived suppressive cells promote B cell-mediated immunosuppression via transfer of PD-L1 in glioblastoma. Cancer Immunol Res. 2019;7:1928-43.

32. Mao Y, Wang Y, Dong L, et al. Circulating exosomes from esophageal squamous cell carcinoma mediate the generation of B10 and PD-1high Breg cells. Cancer Sci. 2019;110:2700-10.

33. Ye L, Zhang Q, Cheng Y, et al. Tumor-derived exosomal HMGB1 fosters hepatocellular carcinoma immune evasion by promoting TIM-1+ regulatory B cell expansion. J Immunother Cancer. 2018;6:145.

34. Admyre C, Bohle B, Johansson SM, et al. B cell-derived exosomes can present allergen peptides and activate allergen-specific T cells to proliferate and produce TH2-like cytokines. J Allergy Clin Immunol. 2007;120:1418-24.

35. Park CS, Choi YS. How do follicular dendritic cells interact intimately with B cells in the germinal centre? Immunology. 2005;114:2-10.

36. Ayre DC, Christian SL. CD24: a rheostat that modulates cell surface receptor signaling of diverse receptors. Front Cell Dev Biol. 2016;4:146.

37. Ayre DC, Chute IC, Joy AP, et al. CD24 induces changes to the surface receptors of B cell microvesicles with variable effects on their RNA and protein cargo. Sci Rep. 2017;7:8642.

38. Liu Y, Chen GY, Zheng P. CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns. Trends Immunol. 2009;30:557-61.

39. Wang Y, Liu J, Burrows PD, Wang J-Y. B cell development and maturation. Adv Exp Med Biol. 2020;1254:1-22.

40. Saunderson SC, Schuberth PC, Dunn AC, et al. Induction of exosome release in primary B cells stimulated via CD40 and the IL-4 receptor. J Immunol. 2008;180:8146-52.

41. Rival C, Mandal M, Cramton K, et al. B cells secrete functional antigen-specific IgG antibodies on extracellular vesicles. Sci Rep. 2024;14:16970.

42. Gutknecht MF, Holodick NE, Rothstein TL. B cell extracellular vesicles contain monomeric IgM that binds antigen and enters target cells. iScience. 2023;26:107526.

43. Lydyard PM, Brostoff J, Hudspith BN, Parry H. Prostaglandin E2-mediated enhancement of human plasma cell differentiation. Immunol Lett. 1982;4:113-6.

44. Subra C, Grand D, Laulagnier K, et al. Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins. J Lipid Res. 2010;51:2105-20.

45. Kalinski P. Regulation of immune responses by prostaglandin E2. J Immunol. 2012;188:21-8.

46. Mittelbrunn M, Gutiérrez-Vázquez C, Villarroya-Beltri C, et al. Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat Commun. 2011;2:282.

47. Sun B, Mallampati S, Gong Y, Wang D, Lefebvre V, Sun X. Sox4 is required for the survival of pro-B cells. J Immunol. 2013;190:2080-9.

48. Lü S, Deng J, Liu H, et al. PKM2-dependent metabolic reprogramming in CD4+ T cells is crucial for hyperhomocysteinemia-accelerated atherosclerosis. J Mol Med. 2018;96:585-600.

49. Buchner M. Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia. FEBS Lett. 2025;599:2896-910.

50. Phan HD, Mayne KE, Squires WRB, et al. CD24 regulates the formation of ectosomes in B lymphocytes. J Extracell Vesicles. 2025;14:e70093.

51. Bonvini P, Zorzi E, Basso G, Rosolen A. Bortezomib-mediated 26S proteasome inhibition causes cell-cycle arrest and induces apoptosis in CD-30+ anaplastic large cell lymphoma. Leukemia. 2007;21:838-42.

52. Crompot E, Van Damme M, Pieters K, et al. Extracellular vesicles of bone marrow stromal cells rescue chronic lymphocytic leukemia B cells from apoptosis, enhance their migration and induce gene expression modifications. Haematologica. 2017;102:1594-604.

53. Faict S, Oudaert I, D’Auria L, et al. The transfer of sphingomyelinase contributes to drug resistance in multiple myeloma. Cancers. 2019;11:1823.

54. Stavnezer J, Guikema JE, Schrader CE. Mechanism and regulation of class switch recombination. Annu Rev Immunol. 2008;26:261-92.

55. Duan Z, Luo Y. Targeting macrophages in cancer immunotherapy. Signal Transduct Target Ther. 2021;6:127.

56. Li M, Jiang P, Wei S, Wang J, Li C. The role of macrophages-mediated communications among cell compositions of tumor microenvironment in cancer progression. Front Immunol. 2023;14:1113312.

57. Klinker MW, Lizzio V, Reed TJ, Fox DA, Lundy SK. Human B cell-derived lymphoblastoid cell lines constitutively produce fas ligand and secrete MHCII+FasL+ killer exosomes. Front Immunol. 2014;5:144.

58. Shao Q, Deng L, Liu H, et al. Involvement of MM cell-derived exosomes in T lymphocytes immune responses. Oncol Lett. 2020;20:31.

59. Zhang F, Li R, Yang Y, et al. Specific decrease in B-cell-derived extracellular vesicles enhances post-chemotherapeutic CD8+ T cell responses. Immunity. 2019;50:738-50.e7.

60. Aung T, Chapuy B, Vogel D, et al. Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3. Proc Natl Acad Sci U S A. 2011;108:15336-41.

61. Lindenbergh MFS, Stoorvogel W. Antigen presentation by extracellular vesicles from professional antigen-presenting cells. 2018; Epub ahead of print.

62. Papp K, Végh P, Prechl J, et al. B lymphocytes and macrophages release cell membrane deposited C3-fragments on exosomes with T cell response-enhancing capacity. Mol Immunol. 2008;45:2343-51.

63. Vidriales MB, San-Miguel JF, Orfao A, Coustan-Smith E, Campana D. Minimal residual disease monitoring by flow cytometry. Best Pract Res Clin Haematol. 2003;16:599-612.

64. Caivano A, Laurenzana I, De Luca L, et al. High serum levels of extracellular vesicles expressing malignancy-related markers are released in patients with various types of hematological neoplastic disorders. Tumour Biol. 2015;36:9739-52.

65. Li JW, Shi D, Wan XC, et al. Universal extracellular vesicles and PD-L1+ extracellular vesicles detected by single molecule array technology as circulating biomarkers for diffuse large B cell lymphoma. Oncoimmunology. 2021;10:1995166.

66. Matthiesen R, Gameiro P, Henriques A, et al. Extracellular vesicles in diffuse large B cell lymphoma: characterization and diagnostic potential. Int J Mol Sci. 2022;23:13327.

67. Akil H, Bentayeb H, Aitamer M, et al. Analysis of CD20 and PD-L1 levels on small extracellular vesicles (sEV) produced by DLBCL cells and EBV-transformed B cells, and potential role in T cell inhibition. Exp Hematol Oncol. 2024;13:53.

68. Yeh YY, Ozer HG, Lehman AM, et al. Characterization of CLL exosomes reveals a distinct microRNA signature and enhanced secretion by activation of BCR signaling. Blood. 2015;125:3297-305.

69. De Luca L, D’Arena G, Simeon V, et al. Characterization and prognostic relevance of circulating microvesicles in chronic lymphocytic leukemia. Leuk Lymphoma. 2017;58:1424-32.

70. Di Noto G, Bugatti A, Zendrini A, et al. Merging colloidal nanoplasmonics and surface plasmon resonance spectroscopy for enhanced profiling of multiple myeloma-derived exosomes. Biosens Bioelectron. 2016;77:518-24.

71. Longjohn MN, Hudson JBJ, Peña-Castillo L, et al. Extracellular vesicle small RNA cargo discriminates non-cancer donors from pediatric B-lymphoblastic leukemia patients. Front Oncol. 2023;13:1272883.

72. Magalhães-Gama F, Malheiros Araújo Silvestrini M, Neves JCF, et al. Exploring cell-derived extracellular vesicles in peripheral blood and bone marrow of B-cell acute lymphoblastic leukemia pediatric patients: proof-of-concept study. Front Immunol. 2024;15:1421036.

73. Saidu NEB, Aarsund M, Sørensen E, et al. Identifying a core protein signature of small extracellular vesicles derived from B-cell precursor acute lymphoblastic leukaemia. Scand J Immunol. 2024;99:e13341.

74. Miljkovic-Licina M, Arraud N, Zahra AD, Ropraz P, Matthes T. Quantification and phenotypic characterization of extracellular vesicles from patients with acute myeloid and B-cell lymphoblastic leukemia. Cancers. 2021;14:56.

75. Provencio M, Rodríguez M, Cantos B, et al. mRNA in exosomas as a liquid biopsy in non-hodgkin lymphoma: a multicentric study by the spanish lymphoma oncology group. Oncotarget. 2017;8:50949-57.

76. Liao Z, Jaular LM, Soueidi E, et al. Acetylcholinesterase is not a generic marker of extracellular vesicles. J Extracell Vesicles. 2019;8:1628592.

77. Rzepiel A, Horváth A, Kutszegi N, et al. MiR-128-3p as blood based liquid biopsy biomarker in childhood acute lymphoblastic leukemia. Mol Cell Probes. 2023;67:101893.

78. Martínez LE, Lensing S, Chang D, et al. Plasma extracellular vesicles bearing PD-L1, CD40, CD40L or TNF-RII are significantly reduced after treatment of AIDS-NHL. Sci Rep. 2022;12:9185.

79. Repetto O, Lovisa F, Elia C, et al. Proteomic exploration of plasma exosomes and other small extracellular vesicles in pediatric hodgkin lymphoma: a potential source of biomarkers for relapse occurrence. Diagnostics. 2021;11:917.

80. Khare D, Goldschmidt N, Bardugo A, Gur-Wahnon D, Ben-Dov IZ, Avni B. Plasma microRNA profiling: exploring better biomarkers for lymphoma surveillance. PLoS One. 2017;12:e0187722.

81. Cao D, Cao X, Jiang Y, et al. Circulating exosomal microRNAs as diagnostic and prognostic biomarkers in patients with diffuse large B-cell lymphoma. Hematol Oncol. 2022;40:172-80.

82. Inada K, Okoshi Y, Cho Y, et al. Availability of circulating microRNAs as a biomarker for early diagnosis of diffuse large B-cell lymphoma. OJBD. 2015;05:48-58.

83. Haderk F, Schulz R, Iskar M, et al. Tumor-derived exosomes modulate PD-L1 expression in monocytes. Sci Immunol. 2017;2:eaah5509.

84. Liu J, Han Y, Hu S, et al. Circulating exosomal MiR-107 restrains tumorigenesis in diffuse large B-cell lymphoma by targeting 14-3-3η. Front Cell Dev Biol. 2021;9:667800.

85. Haque S, Vaiselbuh SR. Exosomal DNMT1 mRNA transcript is elevated in acute lymphoblastic leukemia which might reprograms leukemia progression. Cancer Genet. 2022;260-1:57-64.

86. Reiners KS, Shatnyeva O, Vasyutina E, et al. Extracellular vesicles released from chronic lymphocytic leukemia cells exhibit a disease relevant mRNA signature and transfer mRNA to bystander cells. Haematologica. 2017;102:e100-3.

87. Dhondt B, Pinheiro C, Geeurickx E, et al. Benchmarking blood collection tubes and processing intervals for extracellular vesicle performance metrics. J Extracell Vesicles. 2023;12:e12315.

88. Ljungström M, Oltra E. Methods for extracellular vesicle isolation: relevance for encapsulated miRNAs in disease diagnosis and treatment. Genes. 2025;16:330.

89. Ghosh A, Davey M, Chute IC, et al. Rapid isolation of extracellular vesicles from cell culture and biological fluids using a synthetic peptide with specific affinity for heat shock proteins. PLoS One. 2014;9:e110443.

90. Roy JW, Taylor CA, Beauregard AP, et al. A multiparametric extraction method for Vn96-isolated plasma extracellular vesicles and cell-free DNA that enables multi-omic profiling. Sci Rep. 2021;11:8085.

91. Catalano M, O'Driscoll L. Inhibiting extracellular vesicles formation and release: a review of EV inhibitors. J Extracell Vesicles. 2020;9:1703244.

92. Qian L, Chen P, Zhang S, et al. The uptake of extracellular vesicles: research progress in cancer drug resistance and beyond. Drug Resist Updat. 2025;79:101209.

Extracellular Vesicles and Circulating Nucleic Acids
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