REFERENCES
1. Bossardi Ramos R, Adam AP. Molecular mechanisms of vascular damage during lung injury. Adv Exp Med Biol. 2021;1304:95-107.
2. Long ME, Mallampalli RK, Horowitz JC. Pathogenesis of pneumonia and acute lung injury. Clin Sci. 2022;136:747-69.
4. Renard Triché L, Jabaudon M, Chevret S, Constantin JM, Pereira B, Molinari N. Post-hoc mediation analysis of two biomarkers, and survival in acute respiratory distress syndrome. Sci Rep. 2025;15:24935.
5. Lv Y, Yu W, Xuan R, Yang Y, Xue X, Ma X. Human placental mesenchymal stem cells-exosomes alleviate endothelial barrier dysfunction via cytoskeletal remodeling through hsa-miR-148a-3p/ROCK1 pathway. Stem Cells Int. 2024;2024:2172632.
6. Averyanov A, Koroleva I, Konoplyannikov M, et al. First-in-human high-cumulative-dose stem cell therapy in idiopathic pulmonary fibrosis with rapid lung function decline. Stem Cells Transl Med. 2020;9:6-16.
7. Hoang DM, Pham PT, Bach TQ, et al. Stem cell-based therapy for human diseases. Signal Transduct Target Ther. 2022;7:272.
8. Yang X, Ma X, Don O, et al. Mesenchymal stem cells combined with liraglutide relieve acute lung injury through apoptotic signaling restrained by PKA/β-catenin. Stem Cell Res Ther. 2020;11:182.
9. Wu Q, Fu S, Xiao H, et al. Advances in extracellular vesicle nanotechnology for precision theranostics. Adv Sci. 2023;10:e2204814.
10. Welsh JA, Goberdhan DCI, O’Driscoll L, et al.; MISEV Consortium. Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches. J Extracell Vesicles. 2024;13:e12404.
11. Lotfy A, AboQuella NM, Wang H. Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials. Stem Cell Res Ther. 2023;14:66.
12. Zhao R, Wang L, Wang T, Xian P, Wang H, Long Q. Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury. J Control Release. 2022;345:214-30.
13. Zhou Z, Wu S, Li Y, Shao P, Jiang J. Inhibition of macrophage polarization and pyroptosis in collagen-induced arthritis through MSC-exo and ginsenoside Rh2. Arthritis Res Ther. 2025;27:6.
14. Kundu D, Shin SY, Chilian WM, Dong F. The potential of mesenchymal stem cell-derived exosomes in cardiac repair. Int J Mol Sci. 2024;25:13494.
15. Wang C, Zhou H, Wu R, et al. Mesenchymal stem cell-derived exosomes and non-coding RNAs: regulatory and therapeutic role in liver diseases. Biomed Pharmacother. 2023;157:114040.
16. Yousefi Dehbidi M, Goodarzi N, Azhdari MH, Doroudian M. Mesenchymal stem cells and their derived exosomes to combat Covid-19. Rev Med Virol. 2022;32:e2281.
17. Valiukevičius P, Mačiulaitis J, Pangonytė D, et al. Human placental mesenchymal stem cells and derived extracellular vesicles ameliorate lung injury in acute respiratory distress syndrome murine model. Cells. 2023;12:2729.
18. Pellet-Many C, Frankel P, Evans IM, Herzog B, Jünemann-Ramírez M, Zachary IC. Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas. Biochem J. 2011;435:609-18.
19. Muhl L, Folestad EB, Gladh H, et al. Neuropilin 1 binds PDGF-D and is a co-receptor in PDGF-D-PDGFRβ signaling. J Cell Sci. 2017;130:1365-78.
20. Worthington EN, Hagood JS. Therapeutic use of extracellular vesicles for acute and chronic lung disease. Int J Mol Sci. 2020;21:2318.
21. Bosseboeuf E, Chikh A, Chaker AB, et al. Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow. Sci Signal. 2023;16:eabo4863.
22. Zhou L, Luo H, Lee JW. Role of extracellular vesicles in lung diseases. Chin Med J. 2022;135:1765-80.
23. Liu P, Yang S, Shao X, et al. Mesenchymal stem cells-derived exosomes alleviate acute lung injury by inhibiting alveolar macrophage pyroptosis. Stem Cells Transl Med. 2024;13:371-86.
24. Zarrabi M, Shahrbaf MA, Nouri M, et al. Allogenic mesenchymal stromal cells and their extracellular vesicles in COVID-19 induced ARDS: a randomized controlled trial. Stem Cell Res Ther. 2023;14:169.
25. Wang F, Li Y, Wang B, Li J, Peng Z. The safety and efficacy of mesenchymal stromal cells in ARDS: a meta-analysis of randomized controlled trials. Crit Care. 2023;27:31.







