REFERENCES
1. Dhande OS, Stafford BK, Lim JA, Huberman AD. Contributions of retinal ganglion cells to subcortical visual processing and behaviors. Annu Rev Vis Sci. 2015;1:291-328.
2. Yazdankhah M, Shang P, Ghosh S, et al. Role of glia in optic nerve. Prog Retin Eye Res. 2021;81:100886.
3. Tran NM, Shekhar K, Whitney IE, et al. Single-cell profiles of retinal ganglion cells differing in resilience to injury reveal neuroprotective genes. Neuron. 2019;104:1039-55.e12.
4. Jin ZB, Gao ML, Deng WL, et al. Stemming retinal regeneration with pluripotent stem cells. Prog Retin Eye Res. 2019;69:38-56.
5. Noronha NC, Mizukami A, Caliári-Oliveira C, et al. Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies. Stem Cell Res Ther. 2019;10:131.
6. Li H, Su Y, Wang F, Tao F. Exosomes: a new way of protecting and regenerating optic nerve after injury. Hum Cell. 2022;35:771-8.
7. Joo HS, Suh JH, Lee HJ, Bang ES, Lee JM. Current knowledge and future perspectives on mesenchymal stem cell-derived exosomes as a new therapeutic agent. Int J Mol Sci. 2020;21:727.
8. Kim J, Lee SK, Jung M, et al. Extracellular vesicles from IFN-γ-primed mesenchymal stem cells repress atopic dermatitis in mice. J Nanobiotechnology. 2022;20:526.
9. Sanap A, Kheur S, Kharat A, Bhonde R. Ascorbic acid and IFNγ preconditioning enhance the potency of human mesenchymal stem cells to ameliorate LPS induced cytokine storm. Int Immunopharmacol. 2023;122:110643.
10. Jacobi A, Tran NM, Yan W, et al. Overlapping transcriptional programs promote survival and axonal regeneration of injured retinal ganglion cells. Neuron. 2022;110:2625-45.e7.
11. Wu X, Yu N, Ye Z, et al. Inhibition of cGAS-STING pathway alleviates neuroinflammation-induced retinal ganglion cell death after ischemia/reperfusion injury. Cell Death Dis. 2023;14:615.
12. Au NPB, Ma CHE. Neuroinflammation, microglia and implications for retinal ganglion cell survival and Axon regeneration in traumatic optic neuropathy. Front Immunol. 2022;13:860070.
13. He J, Fu Y, Ge L, et al. Disease-associated microglial activation prevents photoreceptor degeneration by suppressing the accumulation of cell debris and neutrophils in degenerating rat retinas. Theranostics. 2022;12:2687-706.
14. He J, Zhao C, Dai J, et al. Microglia mediate synaptic material clearance at the early stage of rats with retinitis pigmentosa. Front Immunol. 2019;10:912.
15. Liu YY, Li Y, Wang L, et al. Mesenchymal stem cell-derived exosomes regulate microglia phenotypes: a promising treatment for acute central nervous system injury. Neural Regen Res. 2023;18:1657-65.
16. Xin Q, Zhu W, He C, Liu T, Wang H. The effect of different sources of mesenchymal stem cells on microglia states. Front Aging Neurosci. 2023;15:1237532.
17. Paolicelli RC, Sierra A, Stevens B, et al. Microglia states and nomenclature: a field at its crossroads. Neuron. 2022;110:3458-83.
18. Li C, Ren J, Zhang M, et al. The heterogeneity of microglial activation and its epigenetic and non-coding RNA regulations in the immunopathogenesis of neurodegenerative diseases. Cell Mol Life Sci. 2022;79:511.
19. Benhar I, Ding J, Yan W, et al. Temporal single-cell atlas of non-neuronal retinal cells reveals dynamic, coordinated multicellular responses to central nervous system injury. Nat Immunol. 2023;24:700-13.
20. Roy ER, Chiu G, Li S, et al. Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques. Immunity. 2022;55:879-94.e6.
21. Keren-Shaul H, Spinrad A, Weiner A, et al. A unique microglia type associated with restricting development of Alzheimer’s disease. Cell. 2017;169:1276-90.e17.
22. Mead B, Thompson A, Scheven BA, Logan A, Berry M, Leadbeater W. Comparative evaluation of methods for estimating retinal ganglion cell loss in retinal sections and wholemounts. PLoS One. 2014;9:e110612.
23. McWhorter FY, Wang T, Nguyen P, Chung T, Liu WF. Modulation of macrophage phenotype by cell shape. Proc Natl Acad Sci U S A. 2013;110:17253-8.
24. A L, Qu L, He J, et al. Exosomes derived from IFNγ-stimulated mesenchymal stem cells protect photoreceptors in RCS rats by restoring immune homeostasis through tsRNAs. Cell Commun Signal. 2024;22:543.
25. Ozaki E, Delaney C, Campbell M, Doyle SL. Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration. Exp Eye Res. 2022;217:108953.
26. Roy ER, Wang B, Wan YW, et al. Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease. J Clin Invest. 2020;130:1912-30.
27. Mead B, Tomarev S. Bone marrow-derived mesenchymal stem cells-derived exosomes promote survival of retinal ganglion cells through miRNA-dependent mechanisms. Stem Cells Transl Med. 2017;6:1273-85.
28. Manai F, Smedowski A, Kaarniranta K, Comincini S, Amadio M. Extracellular vesicles in degenerative retinal diseases: a new therapeutic paradigm. J Control Release. 2024;365:448-68.
29. Palanisamy CP, Pei J, Alugoju P, et al. New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs). Theranostics. 2023;13:4138-65.
30. Zhang Q, Fu L, Liang Y, et al. Exosomes originating from MSCs stimulated with TGF-β and IFN-γ promote Treg differentiation. J Cell Physiol. 2018;233:6832-40.
31. Harting MT, Srivastava AK, Zhaorigetu S, et al. Inflammation-stimulated mesenchymal stromal cell-derived extracellular vesicles attenuate inflammation. Stem Cells. 2018;36:79-90.
32. Yu C, Roubeix C, Sennlaub F, Saban DR. Microglia versus monocytes: distinct roles in degenerative diseases of the retina. Trends Neurosci. 2020;43:433-49.
33. Mou Q, Yao K, Ye M, et al. Modulation of Sirt1-mTORC1 pathway in microglia attenuates retinal ganglion cell loss after optic nerve injury. J Inflamm Res. 2021;14:6857-69.
34. Hilla AM, Diekmann H, Fischer D. Microglia are irrelevant for neuronal degeneration and Axon regeneration after acute injury. J Neurosci. 2017;37:6113-24.
35. Madry C, Kyrargyri V, Arancibia-Cárcamo IL, et al. Microglial ramification, surveillance, and interleukin-1β release are regulated by the two-pore domain K+ channel THIK-1. Neuron. 2018;97:299-312.e6.
36. Wang Y, Qin WY, Wang Q, et al. Young Sca-1+ bone marrow stem cell-derived exosomes preserve visual function via the miR-150-5p/MEKK3/JNK/c-Jun pathway to reduce M1 microglial polarization. J Nanobiotechnology. 2023;21:194.
37. Wang S, Sudan R, Peng V, et al. TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways. Cell. 2022;185:4153-69.e19.
38. Li RY, Qin Q, Yang HC, et al. TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target. Mol Neurodegener. 2022;17:40.
39. Mathys H, Adaikkan C, Gao F, et al. Temporal tracking of microglia activation in neurodegeneration at single-cell resolution. Cell Rep. 2017;21:366-80.
40. Yang HS, Onos KD, Choi K, et al. Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer’ disease. Cell Rep. 2021;34:108739.
41. Sanford SAI, McEwan WA. Type-I interferons in Alzheimer’s disease and other tauopathies. Front Cell Neurosci. 2022;16:949340.
42. Deczkowska A, Baruch K, Schwartz M. Type I/II interferon balance in the regulation of brain physiology and pathology. Trends Immunol. 2016;37:181-92.
43. Udeochu JC, Amin S, Huang Y, et al. Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience. Nat Neurosci. 2023;26:737-50.
44. Liu Y, Wang A, Chen C, et al. Microglial cGAS-STING signaling underlies glaucoma pathogenesis. Proc Natl Acad Sci U S A. 2024;121:e2409493121.
45. Lückoff A, Caramoy A, Scholz R, Prinz M, Kalinke U, Langmann T. Interferon-beta signaling in retinal mononuclear phagocytes attenuates pathological neovascularization. EMBO Mol Med. 2016;8:670-8.
46. Wang W, Chong WP, Li C, et al. Type I interferon therapy limits CNS autoimmunity by inhibiting CXCR3-mediated trafficking of pathogenic effector T cells. Cell Rep. 2019;28:486-97.e4.
47. Kim DW, Tu KJ, Wei A, et al. Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes. Mol Neurodegener. 2022;17:83.
48. Mary A, Mancuso R, Heneka MT. Immune activation in Alzheimer disease. Annu Rev Immunol. 2024;42:585-613.
49. Wang C, Fan L, Khawaja RR, et al. Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy. Nat Commun. 2022;13:1969.
50. MacInnes AW. The role of the ribosome in the regulation of longevity and lifespan extension. Wiley Interdiscip Rev RNA. 2016;7:198-212.
51. Rahimian R, Guruswamy R, Boutej H, Cordeau P Jr, Weng YC, Kriz J. Targeting SRSF3 restores immune mRNA translation in microglia/macrophages following cerebral ischemia. Mol Ther. 2024;32:783-99.
52. Boutej H, Rahimian R, Thammisetty SS, Béland LC, Lalancette-Hébert M, Kriz J. Diverging mRNA and protein networks in activated microglia reveal SRSF3 suppresses translation of highly upregulated innate immune transcripts. Cell Rep. 2017;21:3220-33.
53. Sun N, Victor MB, Park YP, et al. Human microglial state dynamics in Alzheimer’s disease progression. Cell. 2023;186:4386-403.e29.
54. Wang Y, Wernersbach I, Strehle J, et al. Early posttraumatic CSF1R inhibition via PLX3397 leads to time- and sex-dependent effects on inflammation and neuronal maintenance after traumatic brain injury in mice. Brain Behav Immun. 2022;106:49-66.
55. Wang L, Wei X. Exosome-based crosstalk in glaucoma pathogenesis: a focus on oxidative stress and neuroinflammation. Front Immunol. 2023;14:1202704.
56. Wang T, Li Y, Guo M, et al. Exosome-mediated delivery of the neuroprotective peptide PACAP38 promotes retinal ganglion cell survival and axon regeneration in rats with traumatic optic neuropathy. Front Cell Dev Biol. 2021;9:659783.
57. Giunti D, Marini C, Parodi B, et al. Role of miRNAs shuttled by mesenchymal stem cell-derived small extracellular vesicles in modulating neuroinflammation. Sci Rep. 2021;11:1740.
58. Cheng J, Hao J, Jiang X, et al. Ameliorative effects of miR-423-5p against polarization of microglia cells of the M1 phenotype by targeting a NLRP3 inflammasome signaling pathway. Int Immunopharmacology. 2021;99:108006.
59. Jiang LQ, Xia T, Hu YH, et al. IFITM3 inhibits virus-triggered induction of type I interferon by mediating autophagosome-dependent degradation of IRF3. Cell Mol Immunol. 2018;15:858-867.
60. Wu Z, Tang W, Ibrahim FEEM, et al. Aβ induces neuroinflammation and microglia M1 polarization via cGAS-STING-IFITM3 signaling pathway in BV2 cells. Neurochemical Research. 2023:48.
61. Hu FQ, Zhang YP, Yin J, et al. Characterization of autoantibodies and cytokines related to cutaneous lupus erythematosus. Lupus. 2021;30:315-319.
62. Cadiz MP, Jensen TD, Sens JP, et al. Culture shock: microglial heterogeneity, activation, and disrupted single-cell microglial networks in vitro. Mol Neurodegener. 2022;17:26.
63. Pulido-Salgado M, Vidal-Taboada JM, Barriga GG, Solà C, Saura J. RNA-Seq transcriptomic profiling of primary murine microglia treated with LPS or LPS + IFNγ. Sci Rep. 2018;8:16096.
